Liquid biopsy in liver cancer.

Details

Serval ID
serval:BIB_B3C8E46588B1
Type
Article: article from journal or magazin.
Collection
Publications
Title
Liquid biopsy in liver cancer.
Journal
Discovery medicine
Author(s)
Labgaa I., Villanueva A.
ISSN
1944-7930 (Electronic)
ISSN-L
1539-6509
Publication state
Published
Issued date
04/2015
Peer-reviewed
Oui
Volume
19
Number
105
Pages
263-273
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Liver cancer has become the second cause of cancer-related death worldwide. Most patients are still diagnosed at intermediate or advanced stage, where potentially curative treatment options are not recommended. Unlike other solid tumors, there are no validated oncogenic addiction loops and the only systemic agent to improve survival in advanced disease is sorafenib. All phase 3 clinical trials testing molecular therapies after sorafenib have been negative, none of which selected patients based on predictive biomarkers of response. Theoretically, analysis of circulating cancer byproducts (e.g., circulating tumor cells, cell-free nucleic acids), namely "liquid biopsy," could provide easy access to molecular tumor information, improve patients' stratification and allow to assess tumor dynamics over time. Recent technical developments and preliminary data from other malignancies indicate that liquid biopsy might have a role in the future management of cancer patients.
Keywords
Alleles, Biomarkers, Tumor/blood, Biopsy/methods, Carcinoma, Hepatocellular/blood, Carcinoma, Hepatocellular/diagnosis, Carcinoma, Hepatocellular/epidemiology, Clinical Trials as Topic, DNA, Neoplasm/metabolism, Humans, Liver Neoplasms/blood, Liver Neoplasms/diagnosis, Liver Neoplasms/epidemiology, Molecular Targeted Therapy/methods, Neoplastic Cells, Circulating, Niacinamide/analogs & derivatives, Niacinamide/therapeutic use, Phenylurea Compounds/therapeutic use, Prognosis, Sorafenib
Pubmed
Web of science
Create date
15/07/2021 13:33
Last modification date
15/07/2021 13:33
Usage data