Altered orbitofrontal activation in preterm-born young adolescents during performance of a reality filtering task.

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Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_B3BD1078A37E
Type
Article: article from journal or magazin.
Collection
Publications
Title
Altered orbitofrontal activation in preterm-born young adolescents during performance of a reality filtering task.
Journal
NeuroImage. Clinical
Author(s)
Freitas LGA, Liverani M.C., Siffredi V., Schnider A., Borradori Tolsa C., Ha-Vinh Leuchter R., Van De Ville D., Hüppi P.S.
ISSN
2213-1582 (Electronic)
ISSN-L
2213-1582
Publication state
Published
Issued date
2021
Peer-reviewed
Oui
Volume
30
Pages
102668
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Preterm birth is one of the main causes for neurodevelopmental problems, and has been associated with a wide range of impairments in cognitive functions including executive functions and memory. One of the factors contributing to these adverse outcomes is the intrinsic vulnerability of the premature brain. Neuroimaging studies have highlighted structural and functional alterations in several brain regions in preterm individuals across lifetime. The orbitofrontal cortex (OFC) is crucial for a multitude of complex and adaptive behaviours, and its structure is particularly affected by premature birth. Nevertheless, studies on the functional impact of prematurity on the OFC are still missing. Orbitofrontal Reality filtering (ORFi) refers to the ability to distinguish if a thought is relevant to present reality or not. It can be tested using a continuous recognition task and is mediated by the OFC in adults and typically developing young adolescents. Therefore, the ORFi task was used to investigate whether OFC functioning is affected by prematurity. We compared the neural correlates of ORFi in 35 young adolescents born preterm (below 32 weeks of gestation) and aged 10 to 14 years with 25 full term-born controls. Our findings indicate that OFC activation was required only in the full-term group, whereas preterm young adolescents did not involve OFC in processing the ORFi task, despite being able to correctly perform it.
Keywords
Adolescent, Adult, Brain, Executive Function, Female, Humans, Infant, Newborn, Prefrontal Cortex/diagnostic imaging, Pregnancy, Premature Birth, Recognition, Psychology, Orbitofrontal Cortex, Preterm, Reality filtering, fMRI
Pubmed
Web of science
Open Access
Yes
Create date
23/11/2023 11:46
Last modification date
09/08/2024 2:26
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