Immune defence in mice lacking type I and/or type II interferon receptors.

Details

Serval ID
serval:BIB_B3B9CF664377
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Immune defence in mice lacking type I and/or type II interferon receptors.
Journal
Immunological Reviews
Author(s)
van den Broek M.F., Müller U., Huang S., Zinkernagel R.M., Aguet M.
ISSN
0105-2896 (Print)
ISSN-L
0105-2896
Publication state
Published
Issued date
1995
Volume
148
Pages
5-18
Language
english
Abstract
Mice lacking the receptor for type I interferon (IFN-alpha beta, A129 mice), for type II interferon (IFN-gamma, G129 mice) or for both receptors (AG129 mice) have been generated by embryonic stem cell mediated gene targeting and inter-crossing A129 x G129, respectively. The role of the two IFN systems in controlling a range of infections has been studied using these mice. Type I IFN is shown to be responsible for the immune defence against most viral infections tested (Lymphocytic Choriomeningitis Virus, Semliki Forest Virus, Theiler's Virus, Vesicular Stomatitis Virus), type II IFN seems to be of little importance. In Vaccinia Virus and Theiler's Virus infection, however, both IFN systems were found to play a nonredundant role. IFN-gamma was critical for the defence against intracellular bacteria (Mycobacterium, Listeria) and parasites (Leishmania), whereas IFN-alpha beta was not. IFN-alpha beta is produced by virus-infected cells within hours and plays an important role in preventing virus spread early. Production of IFN-gamma on the other hand needs activation of the immune system and plays a major role later, i.e. mostly during the immune response. Data obtained with the mice described here show that both IFN systems seem to have evolved to complement each other in the host defence against a wide variety of infectious agents.
Keywords
Animals, Antigens, CD/immunology, Antigens, CD/metabolism, Bacterial Infections/immunology, Humans, Immunity, Membrane Proteins, Mice, Parasitic Diseases/immunology, Receptor, Interferon alpha-beta, Receptors, Interferon/deficiency, Receptors, Interferon/immunology, Virus Diseases/immunology
Pubmed
Web of science
Create date
28/01/2008 11:37
Last modification date
20/08/2019 15:22
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