Polyclonal rearrangements of the T-cell receptor beta-chain in fatal angioimmunoblastic lymphadenopathy

Details

Serval ID
serval:BIB_B3B7968DF27F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Polyclonal rearrangements of the T-cell receptor beta-chain in fatal angioimmunoblastic lymphadenopathy
Journal
British Journal of Haematology
Author(s)
Knecht  H., Odermatt  B. F., Hayoz  D., Kuhn  L., Bachmann  F.
ISSN
0007-1048 (Print)
Publication state
Published
Issued date
12/1989
Volume
73
Number
4
Pages
491-6
Notes
Journal Article --- Old month value: Dec
Abstract
Genomic rearrangement of germline T-cell antigen receptor (TcR) and immunoglobulin (Ig) genes was studied by Southern blot analysis in seven patients with angioimmunoblastic lymphadenopathy (AILD). In three cases clinically suspected of transformation into malignant lymphoma, hybridization with the TcR beta probe showed markedly dimished intensity in the 11.5 kb germline band after Eco RI digestion and normal germline configuration after Hind III and Bam HI digestion, indicating polyclonal T cell rearrangements. A clonal rearrangement of the TcR beta gene was detected in only one case at initial biopsy. No monoclonal rearrangement of Ig genes was observed. These data show that in some cases of AILD disease progression is indicated by polyclonal TcR rearrangements and not by outgrowth of a malignant clone, supporting the concept of AILD as an immunoregulatory disorder.
Keywords
Blotting, Southern *Gene Rearrangement, beta-Chain T-Cell Antigen Receptor Humans Immunoblastic Lymphadenopathy/*genetics/immunology
Pubmed
Web of science
Create date
17/01/2008 16:38
Last modification date
20/08/2019 15:22
Usage data