Gonadotrophin response to LH-RH in boys with delayed growth and adolescence

Details

Serval ID
serval:BIB_B3853B7D9A9F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Gonadotrophin response to LH-RH in boys with delayed growth and adolescence
Journal
Archives of Disease in Childhood
Author(s)
Savage  M. O., Preece  M. A., Cameron  N., Jones  J., Theintz  G., Penfold  J. L., Tanner  J. M.
ISSN
1468-2044 (Electronic)
Publication state
Published
Issued date
07/1981
Volume
56
Number
7
Pages
552-6
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
Abstract
Plasma luteinising hormone (LH) and follicle-stimulating hormone (FSH) concentrations were measured before and after intravenous luteinising hormone-releasing hormone (LH-RH) in 33 boys with growth delay. Eighteen were prepubertal and 15 pubertal. Basal LH and FSH levels were low in both groups with mean increments after LH-RH of 3.2 +/- 0.8 U/l (mean +/- SEM) and 2.6 +/- 0.4 U/l respectively in the prepubertal and 7.4 +/- 0.7 U/l and 2.0 +/- 0.3 U/l in the pubertal boys. The LH increment showed a positive correlation with increasing bone age (r = 0.71, P less than 0.001); FSH did not. The LH-RH response thus appeared normal in relation to the stage of maturity.
Keywords
Adolescent Age Determination by Skeleton Body Height Child Dose-Response Relationship, Drug Follicle Stimulating Hormone/*blood Gonadotropin-Releasing Hormone/*diagnostic use Growth Disorders/*blood Humans Luteinizing Hormone/*blood Male Pituitary Function Tests Puberty Puberty, Delayed/blood
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 10:30
Last modification date
20/08/2019 15:22
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