Differential phosphorylation of tau proteins during kitten brain development and Alzheimer's disease.

Details

Serval ID
serval:BIB_B37910CA7847
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Differential phosphorylation of tau proteins during kitten brain development and Alzheimer's disease.
Journal
Journal of Neurocytology
Author(s)
Riederer B.M., Mourton-Gilles C., Frey P., Delacourte A., Probst A.
ISSN
0300-4864 (Print)
ISSN-L
0300-4864
Publication state
Published
Issued date
2001
Volume
30
Number
2
Pages
145-158
Language
english
Abstract
Differential distribution and phosphorylation of tau proteins were studied in developing kitten brain by using several antibodies, and was compared to phosphorylation in Alzheimer's disease. Several antibodies demonstrated the presence of phosphorylated tau proteins during kitten brain development and identified pathological structures in human brain tissue. Antibody AD2, recognized tau in kittens and adult cats, but reacted in Alzheimer's tissue only with a pathological tau form. Antibody AT8 was prominent in developing kitten neurons and was found in axons and dendrites. After the first postnatal month this phosphorylation type disappeared from axons. Furthermore, dephosphorylation of kitten tau with alkaline phosphatase abolished immunoreactivity of AT8, but not that of AD2, pointing to a protection of the AD2 epitope in cats. Tau proteins during early cat brain development are phosphorylated at several sites that are also phosphorylated in paired helical filaments during Alzheimer's disease. In either event, phosphorylation of tau may play a crucial role to modulate microtubule dynamics, contributing to increased microtubule instability and promoting growth of processes during neuronal development or changing dynamic properties of the cytoskeleton and contributing to the formation of pathological structures in neurodegenerative diseases.
Keywords
Aged, Aged, 80 and over, Aging/metabolism, Alzheimer Disease/metabolism, Animals, Animals, Newborn, Brain/growth & development, Brain/metabolism, Cats, Electrophoresis, Polyacrylamide Gel, Female, Humans, Immunoblotting, Immunohistochemistry, Male, Phosphorylation, tau Proteins/metabolism
Pubmed
Web of science
Create date
24/01/2008 15:34
Last modification date
20/08/2019 16:22
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