The relationship between early administration of morphine or nitrous oxide gas and PTSD symptom development.

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Version: author
License: CC BY 4.0
Serval ID
serval:BIB_B30CF1DD9BDC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The relationship between early administration of morphine or nitrous oxide gas and PTSD symptom development.
Journal
Journal of affective disorders
Author(s)
Deforges C., Stuijfzand S., Noël Y., Robertson M., Breines Simonsen T., Eberhard-Gran M., Garthus-Niegel S., Horsch A.
ISSN
1573-2517 (Electronic)
ISSN-L
0165-0327
Publication state
Published
Issued date
15/02/2021
Peer-reviewed
Oui
Volume
281
Pages
557-566
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Posttraumatic Stress Disorder (PTSD) is a debilitating mental health disorder. Certain drugs, such as morphine and nitrous oxide gas (N <sub>2</sub> O), are administered to individuals who just experienced a traumatic event (e.g., soldiers, injured civilians). It is therefore crucial to understand if they incidentally affect PTSD symptom development. Furthermore, such observations could pave the way for the development of pharmacological prevention strategies of PTSD.
In this prospective population-based cohort study (n = 2,070), we examined the relationship between morphine or N <sub>2</sub> O administration during childbirth, and subsequent childbirth-related PTSD symptoms at eight weeks postpartum. Pain during labour, prior PTSD symptoms, and birth medical severity were included as covariates in the analyses.
In women who developed PTSD symptoms, N <sub>2</sub> O administration during childbirth predicted reduced PTSD symptom severity (p < .001, small to medium effect size). A similar tendency was observed for morphine, but was not significant (p < .065, null to small effect size). Both drugs predicted increased PTSD symptoms when combined with severe pain during labour.
This study was observational, thus drug administration was not randomised. Additionally, PTSD symptoms were self-reported.
Peritraumatic N <sub>2</sub> O administration may reduce subsequent PTSD symptom severity and thus be a potential avenue for PTSD secondary prevention. This might also be the case for morphine. However, the role of severe peritraumatic pain in context of drug administration deserves further investigation.
Keywords
Clinical Psychology, Psychiatry and Mental health, Memory consolidation, Morphine, Nitrous Oxide, Pain, Posttraumatic stress disorder, Prevention
Pubmed
Web of science
Open Access
Yes
Create date
06/01/2021 11:33
Last modification date
13/03/2021 6:22
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