Consensus Definitions of Cytomegalovirus (CMV) Infection and Disease in Transplant Patients Including Resistant and Refractory CMV for Use in Clinical Trials: 2024 Update From the Transplant Associated Virus Infections Forum.

Details

Serval ID
serval:BIB_B2FFDC3344BC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Consensus Definitions of Cytomegalovirus (CMV) Infection and Disease in Transplant Patients Including Resistant and Refractory CMV for Use in Clinical Trials: 2024 Update From the Transplant Associated Virus Infections Forum.
Journal
Clinical infectious diseases
Author(s)
Ljungman P., Chemaly R.F., Khawaya F., Alain S., Avery R., Badshah C., Boeckh M., Fournier M., Hodowanec A., Komatsu T., Limaye A.P., Manuel O., Natori Y., Navarro D., Pikis A., Razonable R.R., Westman G., Miller V., Griffiths P.D., Kotton C.N.
Working group(s)
CMV Definitions Working Group of the Transplant Associated Virus Infections Forum
Contributor(s)
Hodowanec A., Komatsu T., Piki A., Westman G., Caliendo A., Chou S., Humar A., Randhawa P., Slavin M., Wong M., Wolf D.
ISSN
1537-6591 (Electronic)
ISSN-L
1058-4838
Publication state
Published
Issued date
26/09/2024
Peer-reviewed
Oui
Volume
79
Number
3
Pages
787-794
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Cytomegalovirus (CMV) infection and disease are important causes of morbidity and mortality in transplant recipients. For the purpose of developing consistent reporting of CMV outcomes in clinical trials, definitions of CMV infection and disease were developed and most recently published in 2017. Since then, there have been major developments, including registration of new antiviral agents. Therefore, the Transplant Associated Virus Infections Forum, which consists of scientists, clinicians, regulators, and industry representatives, has produced an updated version of these definitions that incorporates recent knowledge with the aim of supporting clinical research and drug development. This also includes an update regarding the definition of resistant and refractory CMV infections previously published in 2019. As the field evolves, the need for updates of these definitions is clear, and collaborative efforts among clinicians, scientists, regulators, and industry representatives can provide a platform for this work.
Keywords
Humans, Cytomegalovirus Infections/drug therapy, Cytomegalovirus Infections/virology, Cytomegalovirus Infections/diagnosis, Antiviral Agents/therapeutic use, Cytomegalovirus/drug effects, Transplant Recipients, Clinical Trials as Topic, Consensus, Drug Resistance, Viral, Organ Transplantation/adverse effects, CMV, clinical trials, disease definitions, organ transplantation, stem cell transplantation
Pubmed
Web of science
Open Access
Yes
Create date
26/07/2024 13:56
Last modification date
01/10/2024 7:07
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