Beneficial effect of insulin-like growth factor-1 on hypoxemic renal dysfunction in the newborn rabbit.

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Serval ID
serval:BIB_B2FF680CCAF5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Beneficial effect of insulin-like growth factor-1 on hypoxemic renal dysfunction in the newborn rabbit.
Journal
Pediatric Nephrology
Author(s)
Prévot A., Julita M., Tung D.K., Mosig D.
ISSN
1432-198X[electronic]
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
24
Number
5
Pages
973-981
Language
english
Abstract
Acute normocapnic hypoxemia can cause functional renal insufficiency by increasing renal vascular resistance (RVR), leading to renal hypoperfusion and decreased glomerular filtration rate (GFR). Insulin-like growth factor 1 (IGF-1) activity is low in fetuses and newborns and further decreases during hypoxia. IGF-1 administration to humans and adult animals induces pre- and postglomerular vasodilation, thereby increasing GFR and renal blood flow (RBF). A potential protective effect of IGF-1 on renal function was evaluated in newborn rabbits with hypoxemia-induced renal insufficiency. Renal function and hemodynamic parameters were assessed in 17 anesthetized and mechanically ventilated newborn rabbits. After hypoxemia stabilization, saline solution (time control) or IGF-1 (1 mg/kg) was given as an intravenous (i.v.) bolus, and renal function was determined for six 30-min periods. Normocapnic hypoxemia significantly increased RVR (+16%), leading to decreased GFR (-14%), RBF (-19%) and diuresis (-12%), with an increased filtration fraction (FF). Saline solution resulted in a worsening of parameters affected by hypoxemia. Contrarily, although mean blood pressure decreased slightly but significantly, IGF-1 prevented a further increase in RVR, with subsequent improvement of GFR, RBF and diuresis. FF indicated relative postglomerular vasodilation. Although hypoxemia-induced acute renal failure was not completely prevented, IGF-1 elicited efferent vasodilation, thereby precluding a further decline in renal function.
Keywords
Animals, Animals, Newborn, Anoxia/complications, Anoxia/drug therapy, Disease Models, Animal, Hemodynamics/drug effects, Injections, Intravenous, Insulin-Like Growth Factor I/administration & dosage, Insulin-Like Growth Factor I/pharmacology, Kidney Diseases/etiology, Kidney Diseases/mortality, Kidney Function Tests, Longevity/drug effects, Rabbits, Renal Circulation/drug effects, Survival Rate, Urinalysis, Vasodilation/drug effects
Pubmed
Web of science
Open Access
Yes
Create date
17/07/2009 16:32
Last modification date
01/10/2019 6:19
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