Comparison of Methods for Improving Fracture Risk Assessment in Diabetes: The Manitoba BMD Registry.
Details
Serval ID
serval:BIB_B2A5A59872F3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Comparison of Methods for Improving Fracture Risk Assessment in Diabetes: The Manitoba BMD Registry.
Journal
Journal of bone and mineral research
ISSN
1523-4681 (Electronic)
ISSN-L
0884-0431
Publication state
Published
Issued date
11/2018
Peer-reviewed
Oui
Volume
33
Number
11
Pages
1923-1930
Language
english
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Type 2 diabetes is a risk factor for fracture independent of FRAX (fracture risk assessment) probability. We directly compared four proposed methods to improve the performance of FRAX for type 2 diabetes by: (1) including the rheumatoid arthritis (RA) input to FRAX; (2) making a trabecular bone score (TBS) adjustment to FRAX; (3) reducing the femoral neck T-score input to FRAX by 0.5 SD; and (4) increasing the age input to FRAX by 10 years. We examined major osteoporotic fractures (MOFs) and hip fractures (HFs) over a mean of 8.3 years observation among 44,543 women and men 40 years of age or older (4136 with diabetes) with baseline lumbar spine and hip DXA from 1999 through 2016. Controlled for unadjusted FRAX probability, diabetes was associated with an increased risk for MOFs and HFs. All four FRAX adjustments attenuated the effect of diabetes, but a residual effect of diabetes was seen on MOF risk after TBS adjustment, and on HF risk after the RA and TBS adjustments. Among those with diabetes, unadjusted FRAX risk underestimated MOF (observed/predicted ratio 1.15; 95% CI, 1.03 to 1.28), but this was no longer significant after applying the diabetes adjustments. HF risk was more severely underestimated (observed/predicted ratio 1.85; 95% CI, 1.51 to 2.20) and was only partially corrected with the diabetes adjustments (still significant for the RA and TBS adjustments). Among those with diabetes, there was moderate reclassification based upon a fixed MOF cut-off of 20% (4.1% to 7.1%) or fixed HF cut-off of 3% (5.7% to 16.5%). Net reclassification improvement increased for MOF with each of the diabetes adjustments (range 3.9% to 5.6% in the diabetes subgroup). In conclusion, each of the proposed methods for addressing limitations in the ability of FRAX to assess fracture risk in individuals with diabetes was found to improve performance, though no single method was optimal in all settings. © 2018 American Society for Bone and Mineral Research.
Keywords
Bone Density, Calibration, Canada, Diabetes Mellitus, Type 2/complications, Female, Hip Fractures/epidemiology, Humans, Incidence, Male, Middle Aged, Osteoporotic Fractures/epidemiology, Osteoporotic Fractures/physiopathology, Probability, Registries, Risk Assessment/methods, DIABETES, DXA, FRACTURE RISK ASSESSMENT, FRAX, OSTEOPOROSIS, TRABECULAR BONE SCORE
Pubmed
Web of science
Create date
17/08/2018 17:49
Last modification date
27/10/2019 7:11