Interleukin-1 receptor antagonist gene (IL-1RN) polymorphism is a predictive factor of clinical pregnancy after IVF.

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Serval ID
serval:BIB_B29C8FFE70A1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Interleukin-1 receptor antagonist gene (IL-1RN) polymorphism is a predictive factor of clinical pregnancy after IVF.
Journal
Human Reproduction
Author(s)
Gremlich S., Fratta S., Rebellato E., Uras R., Reymondin D., Damnon F., Germond M., Gerber S.
ISSN
1460-2350[electronic]
Publication state
Published
Issued date
2008
Volume
23
Number
5
Pages
1200-1206
Language
english
Abstract
BACKGROUND: Only 25% of IVF transfer cycles lead to a clinical pregnancy, calling for continued technical progress but also more in depth analysis of patients' individual characteristics. The interleukin-1 (IL-1) system and matrix metalloproteinases (MMPs) are strongly implicated in embryo implantation. The genes coding for IL-1Ra (gene symbol IL-1RN), IL-1beta, MMP2 and MMP9 bear functional polymorphisms. We analysed the maternal genetic profile at these polymorphic sites in IVF patients, to determine possible correlations with IVF outcome. METHODS: One hundred and sixty women undergoing an IVF cycle were enrolled and a buccal smear was obtained. The presence of IL-1RN variable number of tandem repeats and IL-1B + 3953, MMP2-1306 and MMP9-1562 single nucleotide substitutions were determined. Patients were divided into pregnancy failures (119), biochemical pregnancies (8) and clinical pregnancies (33). RESULTS: There was a 40% decrease in IL-1RN*2 allele frequency (P = 0.024) and a 45% decrease in IL-1RN*2 carrier status in the clinical pregnancy group as compared to the pregnancy failure group (P = 0.017). This decrease was still statistically significant after a multivariate logistic regression analysis. The likelihood of a clinical pregnancy was decreased accordingly in IL-1RN*2 carriers: odds ratio = 0.349, 95% confidence interval = 0.2-0.8, P = 0.017. The IL-1B, MMP2 and MMP9 polymorphisms showed no correlation with IVF outcome. CONCLUSIONS: IL-1RN*2 allele carriage is associated with a poor prognosis of achieving a pregnancy after IVF.
Keywords
Adult, Cohort Studies, Cryopreservation, Female, Fertilization in Vitro, Gene Frequency, Humans, Interleukin 1 Receptor Antagonist Protein, Logistic Models, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Polymorphism, Genetic, Pregnancy, Pregnancy Outcome, Prospective Studies, Treatment Outcome
Pubmed
Web of science
Open Access
Yes
Create date
05/03/2009 15:50
Last modification date
25/09/2019 7:10
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