Interleukin-1 receptor antagonist gene (IL-1RN) polymorphism is a predictive factor of clinical pregnancy after IVF.

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Serval ID
serval:BIB_B29C8FFE70A1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Interleukin-1 receptor antagonist gene (IL-1RN) polymorphism is a predictive factor of clinical pregnancy after IVF.
Journal
Human reproduction
Author(s)
Gremlich S., Fratta S., Rebellato E., Uras R., Reymondin D., Damnon F., Germond M., Gerber S.
ISSN
1460-2350 (Electronic)
ISSN-L
0268-1161
Publication state
Published
Issued date
05/2008
Peer-reviewed
Oui
Volume
23
Number
5
Pages
1200-1206
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Only 25% of IVF transfer cycles lead to a clinical pregnancy, calling for continued technical progress but also more in depth analysis of patients' individual characteristics. The interleukin-1 (IL-1) system and matrix metalloproteinases (MMPs) are strongly implicated in embryo implantation. The genes coding for IL-1Ra (gene symbol IL-1RN), IL-1beta, MMP2 and MMP9 bear functional polymorphisms. We analysed the maternal genetic profile at these polymorphic sites in IVF patients, to determine possible correlations with IVF outcome.
One hundred and sixty women undergoing an IVF cycle were enrolled and a buccal smear was obtained. The presence of IL-1RN variable number of tandem repeats and IL-1B + 3953, MMP2-1306 and MMP9-1562 single nucleotide substitutions were determined. Patients were divided into pregnancy failures (119), biochemical pregnancies (8) and clinical pregnancies (33).
There was a 40% decrease in IL-1RN*2 allele frequency (P = 0.024) and a 45% decrease in IL-1RN*2 carrier status in the clinical pregnancy group as compared to the pregnancy failure group (P = 0.017). This decrease was still statistically significant after a multivariate logistic regression analysis. The likelihood of a clinical pregnancy was decreased accordingly in IL-1RN*2 carriers: odds ratio = 0.349, 95% confidence interval = 0.2-0.8, P = 0.017. The IL-1B, MMP2 and MMP9 polymorphisms showed no correlation with IVF outcome.
IL-1RN*2 allele carriage is associated with a poor prognosis of achieving a pregnancy after IVF.
Keywords
Adult, Cohort Studies, Cryopreservation, Female, Fertilization in Vitro, Gene Frequency, Humans, Interleukin 1 Receptor Antagonist Protein/genetics, Logistic Models, Matrix Metalloproteinase 2/genetics, Matrix Metalloproteinase 9/genetics, Polymorphism, Genetic, Pregnancy, Pregnancy Outcome, Prospective Studies, Treatment Outcome
Pubmed
Web of science
Open Access
Yes
Create date
05/03/2009 15:50
Last modification date
15/05/2024 6:59
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