Long‐term efficacy, tolerability, and retention of brivaracetam in epilepsy treatment: A longitudinal multicenter study with up to 5 years of follow‐up
Details
Serval ID
serval:BIB_B2791038BA7B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Long‐term efficacy, tolerability, and retention of brivaracetam in epilepsy treatment: A longitudinal multicenter study with up to 5 years of follow‐up
Journal
Epilepsia
ISSN
0013-9580
1528-1167
1528-1167
Publication state
Published
Issued date
12/2021
Peer-reviewed
Oui
Volume
62
Number
12
Pages
2994-3004
Language
english
Abstract
Objective: To analyze the association between electroencephalographic (EEG) patterns and overall, short- and long-term mortality in patients with hypoxic encephalopathy (HE).
Methods: Retrospective, mono-center analysis of 199 patients using univariate log-rank tests (LR) and multivariate cox regression (MCR).
Results: Short-term mortality, defined as death within 30-days post-discharge was 54.8%. Long-term mortality rates were 69.8%, 71.9%, and 72.9%, at 12-, 24-, and 36-months post-HE, respectively. LR revealed a significant association between EEG suppression (SUP) and short-term mortality, and identified low voltage EEG (LV), burst suppression (BSP), periodic discharges (PD) and post-hypoxic status epilepticus (PSE) as well as missing (aBA) or non-reactive background activity (nrBA) as predictors for overall, short- and long-term mortality. MCR indicated SUP, LV, BSP, PD, aBA and nrBA as significantly associated with overall and short-term mortality to varying extents. LV and BSP were significant predictors for long-term mortality in short-term survivors. Rhythmic delta activity, stimulus induced rhythmic, periodic or ictal discharges and sharp waves were not significantly associated with a higher mortality.
Conclusion: The presence of several specific EEG patterns can help to predict overall, short- and long-term mortality in HE patients.
Significance: The present findings may help to improve the challenging prognosis estimation in HE patients.
Methods: Retrospective, mono-center analysis of 199 patients using univariate log-rank tests (LR) and multivariate cox regression (MCR).
Results: Short-term mortality, defined as death within 30-days post-discharge was 54.8%. Long-term mortality rates were 69.8%, 71.9%, and 72.9%, at 12-, 24-, and 36-months post-HE, respectively. LR revealed a significant association between EEG suppression (SUP) and short-term mortality, and identified low voltage EEG (LV), burst suppression (BSP), periodic discharges (PD) and post-hypoxic status epilepticus (PSE) as well as missing (aBA) or non-reactive background activity (nrBA) as predictors for overall, short- and long-term mortality. MCR indicated SUP, LV, BSP, PD, aBA and nrBA as significantly associated with overall and short-term mortality to varying extents. LV and BSP were significant predictors for long-term mortality in short-term survivors. Rhythmic delta activity, stimulus induced rhythmic, periodic or ictal discharges and sharp waves were not significantly associated with a higher mortality.
Conclusion: The presence of several specific EEG patterns can help to predict overall, short- and long-term mortality in HE patients.
Significance: The present findings may help to improve the challenging prognosis estimation in HE patients.
Keywords
Neurology (clinical), Neurology, Cardiac arrest, post-anoxic coma, EEG, prognostication
Pubmed
Web of science
Open Access
Yes
Create date
17/06/2022 16:20
Last modification date
10/11/2023 8:11