Effects of infused amino acids and lipids on glucose metabolism in healthy lean humans.

Details

Serval ID
serval:BIB_B25C5BEB2A13
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effects of infused amino acids and lipids on glucose metabolism in healthy lean humans.
Journal
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity
Author(s)
Haesler E., Schneiter P., Temler E., Jéquier E., Tappy L.
ISSN
0307-0565
Publication state
Published
Issued date
1994
Peer-reviewed
Oui
Volume
18
Number
5
Pages
307-12
Language
english
Notes
Publication types: Clinical Trial ; Controlled Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
The effects of infusion of a triglyceride emulsion (which induces peripheral insulin resistance) and amino acids (which stimulate gluconeogenesis) on glucose metabolism were investigated in healthy lean humans during exogenous infusion of glucose. One group of subjects (n = 5) was infused for 7.5 h with 11.1 mumol/kg/min glucose; during the last 4 h, amino acids were also infused at a rate of 3.33 mg/kg/min. A second group of subjects (n = 5) was infused with glucose+lipids (Lipovenös, 10% 10 ml/min) for 7.5 h and amino acids were added during the last 4 h. Infusion of lipids suppressed the increase in glucose oxidation observed during infusion of glucose alone (delta glucose oxidation: -2.1 +/- 1.1 vs. + 4.5 +/- 1.4 mumol/kg/min; P < 0.05) and during infusion of glucose+amino acids (delta glucose oxidation: + 1.6 +/- 1.4 vs. + 10.6 +/- 1.2 mumol/kg/min; P < 0.05). Gluconeogenesis (determined from 13C glucose synthesis during infusion of 13C bicarbonate) increased from 1.1 +/- 0.2 mumol/kg/min during infusion of glucose and 1.6 +/- 0.3 during infusion of glucose+lipids to 3.2 +/- 0.4 and 3.1 +/- 0.4, respectively, when amino acid infusion was superimposed (P < 0.05 in both instances). Plasma glucose concentrations were identical during infusion of glucose alone or glucose+amino acids, with or without lipids. Insulin concentrations were significantly increased by lipids both during infusion of glucose alone and of glucose+amino acids.(ABSTRACT TRUNCATED AT 250 WORDS)
Keywords
Adult, Amino Acids, Blood Glucose, Breath Tests, Fat Emulsions, Intravenous, Fatty Acids, Nonesterified, Female, Gas Chromatography-Mass Spectrometry, Glucagon, Gluconeogenesis, Glucose, Humans, Infusions, Intravenous, Insulin, Lipid Metabolism, Liver, Male, Nitrogen, Oxidation-Reduction, Triglycerides
Pubmed
Web of science
Create date
24/01/2008 14:36
Last modification date
20/08/2019 16:21
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