Prescribing issues in elderly individuals living with HIV.

Details

Serval ID
serval:BIB_B259C3C07593
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prescribing issues in elderly individuals living with HIV.
Journal
Expert review of clinical pharmacology
Author(s)
Marzolini C., Livio F.
ISSN
1751-2441 (Electronic)
ISSN-L
1751-2433
Publication state
Published
Issued date
07/2019
Peer-reviewed
Oui
Volume
12
Number
7
Pages
643-659
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Introduction: Combined antiretroviral therapy has transformed HIV infection into a chronic disease thus people living with HIV (PLWH) live longer. As a result, the management of HIV infection is becoming more challenging as elderly experience age-related comorbidities leading to complex polypharmacy and a higher risk for drug-drug or drug-disease interactions. Furthermore, age-related physiological changes affect pharmacokinetics and pharmacodynamics thereby predisposing elderly PLWH to incorrect dosing or inappropriate prescribing and consequently to adverse drug reactions and the subsequent risk of starting a prescribing cascade. Areas covered: This review discusses the demographics of the aging HIV population, physiological changes and their impact on drug response as well as comorbidities. Particular emphasis is placed on common prescribing issues in elderly PLWH including drug-drug interactions with antiretroviral drugs. A PubMed search was used to compile relevant publications until February 2019. Expert opinion: Prescribing issues are highly prevalent in elderly PLWH thus highlighting the need for education on geriatric prescribing principles. Adverse health outcomes potentially associated with polypharmacy and inappropriate prescribing should promote interventions to prevent harm including medication reconciliation, medication review, and medication prioritization according to the risks/benefits for a given patient. A multidisciplinary team approach is recommended for the care of elderly PLWH.
Keywords
Age Factors, Aged, Aging, Anti-HIV Agents/administration & dosage, Anti-HIV Agents/adverse effects, Drug Interactions, HIV Infections/drug therapy, Humans, Inappropriate Prescribing/prevention & control, Medication Reconciliation/methods, Patient Care Team/organization & administration, Polypharmacy, Practice Patterns, Physicians'/standards, HIV, antiretroviral drug, drug-drug interactions, elderly, inappropriate prescribing, polypharmacy
Pubmed
Create date
17/06/2019 18:06
Last modification date
21/08/2019 6:34
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