Interplay between galanin and leptin in the hypothalamic control of feeding via corticotropin-releasing hormone and neuropeptide Y

Details

Serval ID
serval:BIB_B1F271CE4F0A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Interplay between galanin and leptin in the hypothalamic control of feeding via corticotropin-releasing hormone and neuropeptide Y
Journal
Diabetes
Author(s)
Bergonzelli  G. E., Pralong  F. P., Glauser  M., Cavadas  C., Grouzmann  E., Gaillard  R. C.
ISSN
0012-1797 (Print)
Publication state
Published
Issued date
12/2001
Volume
50
Number
12
Pages
2666-72
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec
Abstract
Over long periods, feeding and metabolism are tightly regulated at the central level. The total amount of nutrients ingested is thought to result from a delicate balance between orexigenic and anorexigenic factors expressed and secreted by specialized hypothalamic neuronal populations. We have developed a system of perifused hypothalamic neurons to characterize the relationships existing between the orexigenic peptide galanin and two other physiological modulators of feeding: neuropeptide Y (NPY) and corticotropin-releasing hormone (CRH). We demonstrated that galanin stimulates CRH and NPY secretion from hypothalamic neurons in a dose-dependent manner. Exposure to leptin for 24 h before galanin stimulation decreased NPY secretion by 30%, leaving the responsiveness of CRH neurons intact. These results suggest that CRH and NPY neurons participate to the intrahypothalamic signaling pathway of galanin, an observation that can explain the lower potency of galanin to stimulate food intake in vivo compared with NPY. The differential effects exerted by leptin on CRH and NPY suggest that there exists a subset of NPY neurons that are exquisitely sensitive to marked variations in leptin levels, and that the CRH neurons are less responsive to increases in leptin concentrations.
Keywords
Animals Axons/ultrastructure Blotting, Northern Cells, Cultured Corticotropin-Releasing Hormone/genetics/*physiology/secretion Drug Interactions Eating/*physiology Embryo Galanin/administration & dosage/*pharmacology Gene Expression/drug effects Hypothalamus/drug effects/*physiology Immunohistochemistry Leptin/administration & dosage/*pharmacology Microtubule-Associated Proteins/analysis Neurites/ultrastructure Neurons/drug effects/physiology/ultrastructure Neuropeptide Y/genetics/*physiology/secretion RNA, Messenger/analysis Rats Reverse Transcriptase Polymerase Chain Reaction
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 16:26
Last modification date
20/08/2019 15:20
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