Contemporary snapshot of tumor regression grade (TRG) distribution in locally advanced rectal cancer: a cross sectional multicentric experience

Details

Serval ID
serval:BIB_B1CA2AA6E808
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Contemporary snapshot of tumor regression grade (TRG) distribution in locally advanced rectal cancer: a cross sectional multicentric experience
Journal
Updates in Surgery
Author(s)
Germani Paola, Di Candido Francesca, Léonard Daniel, Cuicchi Dajana, Elmore Ugo, Allaix Marco Ettore, Barbieri Vittoria Pia, D'Allens Laura, Faes Seraina, Milani Marika, Caputo Damiano, Martinez Carmen, Grosek Jan, Caracino Valerio, Christou Niki, Roodbeen Sapho X., Bracale Umberto, Wildeboer Aurelia, Usai Antonella, Benedetti Michele, Balani Alessandro, Piccinni Giuseppe, Catarci Marco, Millo Paolo, Bouvy Nicole, Corcione Francesco, Hompes Roel, Ris Frédéric, Basti Massimo, Tomazic Ales, Targarona Eduardo, Coppola Alessandro, Pietrabissa Andrea, Hahnloser Dieter, Adamina Michel, Viola Massimo, Morino Mario, Rosati Riccardo, Poggioli Gilberto, Kartheuser Alex, Spinelli Antonino, de Manzini Nicolò
ISSN
2038-131X
2038-3312
Publication state
Published
Issued date
05/04/2021
Peer-reviewed
Oui
Language
english
Abstract
<jats:title>Abstract</jats:title><jats:p>Pre-operative chemoradiotherapy (CRT) followed by surgical resection is still the standard treatment for locally advanced low rectal cancer. Nowadays new strategies are emerging to treat patients with a complete response to pre-operative treatment, rendering the optimal management still controversial and under debate. The primary aim of this study was to obtain a snapshot of tumor regression grade (TRG) distribution after standard CRT. Second, we aimed to identify a correlation between clinical tumor stage (cT) and TRG, and to define the accuracy of magnetic resonance imaging (MRI) in the restaging setting. Between January 2017 and June 2019, a cross sectional multicentric study was performed in 22 referral centers of colon-rectal surgery including all patients with cT3-4Nx/cTxN1-2 rectal cancer who underwent pre-operative CRT. Shapiro–Wilk test was used for continuous data. Categorical variables were compared with Chi-squared test or Fisher’s exact test, where appropriate. Accuracy of restaging MRI in the identification of pathologic complete response (pCR) was determined evaluating the correspondence with the histopathological examination of surgical specimens.</jats:p><jats:p>In the present study, 689 patients were enrolled. Complete tumor regression rate was 16.9%. The “watch and wait” strategy was applied in 4.3% of TRG4 patients. A clinical correlation between more advanced tumors and moderate to absent tumor regression was found (<jats:italic>p</jats:italic> = 0.03). Post-neoadjuvant MRI had low sensibility (55%) and high specificity (83%) with accuracy of 82.8% in identifying TRG4 and pCR.</jats:p><jats:p>Our data provided a contemporary description of the effects of pre-operative CRT on a large pool of locally advanced low rectal cancer patients treated in different colon-rectal surgical centers.</jats:p>
Keywords
Surgery
Pubmed
Web of science
Open Access
Yes
Create date
16/07/2021 12:18
Last modification date
13/08/2021 6:38
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