Comparison of seven prognostic tools to identify low-risk pulmonary embolism in patients aged <50 years.
Details
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State: Public
Version: author
License: CC BY 4.0
Serval ID
serval:BIB_B17B0EBEA223
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Comparison of seven prognostic tools to identify low-risk pulmonary embolism in patients aged <50 years.
Journal
Scientific reports
Working group(s)
RIETE investigators
Contributor(s)
Adarraga M.D., Aibar M.Á., Aibar J., Amado C., Arcelus J.I., Ballaz A., Barba R., Barrón M., Barrón-Andrés B., Bascuñana J., Blanco-Molina Á., Camón A.M., Cañas I., Carrasco C., Castro J., de Ancos C., Del Toro J., Demelo P., Díaz-Peromingo J.A., Díaz-Simón R., Falgá C., Farfán A.I., Fernández-Capitán C., Del Carmen Fernández-Criado M., Fernández-Núñez S., Fidalgo Á., Font L., García M.A., García-Morillo M., García-Raso A., Gavín-Sebastián O., Del Carmen Gayol M., Gil-Díaz A., Gómez V., Gómez-Cuervo C., González-Martínez J., Grau E., Gutiérrez J., Gutiérrez-González S., Iglesias M., Jaras M.J., Jou I., Joya M.D., Lalueza A., Lima J., Llamas P., Lobo J.L., López-Jiménez L., López-Miguel P., López-Núñez J.J., López-Sáez J.B., Lorente M.A., Lorenzo A., Loring M., Madridano O., Marchena P.J., Martín J.M., Mellado M., Morales MDV, Nieto M.L., Nieto J.A., Núñez M.J., Olivares M.C., Pedrajas J.M., Pellejero G., Pérez-Rus G., Peris M.L., Porras J.A., Rivas A., Rodríguez-Dávila M.Á., Adela Rodríguez-Hernández A., Rubio C.M., Ruiz-Artacho P., Ruiz-Ruiz J., Ruiz-Sada P., Sahuquillo J.C., Salazar V., Sampériz Á., Muñoz-Torrero JFS, Sancho T., Soler S., Suriñach J.M., Tapia E., Tolosa C., Torres M.I., Trujillo-Santos J., Uresandi F., Valle R., Villares P., Gutiérrez P., Vázquez F.J., Vilaseca A., Vanassche T., Vandenbriele C., Verhamme P., Hirmerova J., Malý R., Celis G., Del Pozo G., Salgado E., Benzidia I., Bertoletti L., Bura-Riviere A., Debourdeau P., Farge-Bancel D., Hij A., Mahé I., Moustafa F., Schellong S., Braester A., Brenner B., Tzoran I., Sharif-Kashani B., Barillari G., Bilora F., Bortoluzzi C., Brandolin B., Bucherini E., Ciammaichella M., Dentali F., Di Micco P., Maida R., Mastroiacovo D., Mumoli N., Pace F., Parisi R., Pesavento R., Prandoni P., Quintavalla R., Rocci A., Romualdi R., Sinicalchi C., Tufano A., Visonà A., Hong N.V., Zalunardo B., Gibietis V., Kigitovica D., Skride A., Bosevski M., Bounameaux H., Mazzolai L., Caprini J.A., Bui H.M., Pham K.Q., Reis A.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
27/12/2019
Peer-reviewed
Oui
Volume
9
Number
1
Pages
20064
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Abstract
In young patients with acute pulmonary embolism (PE), the predictive value of currently available prognostic tools has not been evaluated. Our objective was to compare prognostic value of 7 available tools (GPS, PESI, sPESI, Prognostic Algorithm, PREP, shock index and RIETE) in patients aged <50 years. We used the RIETE database, including PE patients from 2001 to 2017. The major outcome was 30-day all-cause mortality. Of 34,651 patients with acute PE, 5,822 (17%) were aged <50 years. Of these, 83 (1.4%) died during the first 30 days. Number of patients deemed low risk with tools was: PREP (95.9%), GPS (89.6%), PESI (87.2%), Shock index (70.9%), sPESI (59.4%), Prognostic algorithm (58%) and RIETE score (48.6%). The tools with a highest sensitivity were: Prognostic Algorithm (91.6%; 95% CI: 85.6-97.5), RIETE score (90.4%; 95%CI: 84.0-96.7) and sPESI (88%; 95% CI: 81-95). The RIETE, Prognostic Algorithm and sPESI scores obtained the highest overall sensitivity estimates for also predicting 7- and 90-day all-cause mortality, 30-day PE-related mortality, 30-day major bleeding and 30-day VTE recurrences. The proportion of low-risk patients who died within the first 30 days was lowest using the Prognostic Algorithm (0.2%), RIETE (0.3%) or sPESI (0.3%) scores. In PE patients less 50 years, 30-day mortality was low. Although sPESI, RIETE and Prognostic Algorithm scores were the most sensitive tools to identify patients at low risk to die, other tools should be evaluated in this population to obtain more efficient results.
Pubmed
Web of science
Open Access
Yes
Create date
26/11/2020 12:17
Last modification date
29/01/2021 6:25
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