Progression of human carotid and femoral atherosclerosis: a prospective follow-up study by magnetic resonance vessel wall imaging.

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Serval ID
serval:BIB_B12C1B56F084
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Progression of human carotid and femoral atherosclerosis: a prospective follow-up study by magnetic resonance vessel wall imaging.
Journal
European Heart Journal
Author(s)
Bianda N., Di Valentino M., Périat D., Segatto J.M., Oberson M., Moccetti M., Sudano I., Santini P., Limoni C., Froio A., Stuber M., Corti R., Gallino A., Wyttenbach R.
ISSN
1522-9645 (Electronic)
ISSN-L
0195-668X
Publication state
Published
Issued date
2012
Volume
33
Number
2
Pages
230-237
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
AIMS: The time course of atherosclerosis burden in distinct vascular territories remains poorly understood. We longitudinally evaluated the natural history of atherosclerotic progression in two different arterial territories using high spatial resolution magnetic resonance imaging (HR-MRI), a powerful, safe, and non-invasive tool.
METHODS AND RESULTS: We prospectively studied a cohort of 30 patients (mean age 68.3, n = 9 females) with high Framingham general cardiovascular disease 10-year risk score (29.5%) and standard medical therapy with mild-to-moderate atherosclerosis intra-individually at the level of both carotid and femoral arteries. A total of 178 HR-MRI studies of carotid and femoral arteries performed at baseline and at 1- and 2-year follow-up were evaluated in consensus reading by two experienced readers for lumen area (LA), total vessel area (TVA), vessel wall area (VWA = TVA - LA), and normalized wall area index (NWI = VWA/TVA). At the carotid level, LA decreased (-3.19%/year, P = 0.018), VWA increased (+3.83%/year, P = 0.019), and TVA remained unchanged. At the femoral level, LA remained unchanged, VWA and TVA increased (+5.23%/year and +3.11%/year, both P < 0.01), and NWI increased for both carotid and femoral arteries (+2.28%/year, P = 0.01, and +1.8%/year, P = 0.033).
CONCLUSION: The atherosclerotic burden increased significantly in both carotid and femoral arteries. However, carotid plaque progression was associated with negative remodelling, whereas the increase in femoral plaque burden was compensated by positive remodelling. This finding could be related to anatomic and flow differences and/or to the distinct degree of obstruction in the two arterial territories.
Keywords
Aged, Atherosclerosis/pathology, Carotid Artery, Common/pathology, Carotid Artery, Internal/pathology, Carotid Stenosis/pathology, Disease Progression, Female, Femoral Artery/pathology, Follow-Up Studies, Humans, Magnetic Resonance Angiography/methods, Male, Middle Aged, Observer Variation, Plaque, Atherosclerotic/pathology, Prospective Studies
Pubmed
Web of science
Open Access
Yes
Create date
16/12/2011 14:21
Last modification date
25/09/2019 6:10
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