Multisensory interactions within human primary cortices revealed by BOLD dynamics.

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Serval ID
serval:BIB_B12AF5A12E11
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Multisensory interactions within human primary cortices revealed by BOLD dynamics.
Journal
Cerebral Cortex
Author(s)
Martuzzi R., Murray M.M., Michel C.M., Thiran J.P., Maeder P.P., Clarke S., Meuli R.A.
ISSN
1047-3211
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
17
Number
7
Pages
1672-1679
Language
english
Abstract
Whether signals from different sensory modalities converge and interact within primary cortices in humans is unresolved, despite emerging evidence in animals. This is partially because of debates concerning the appropriate analyses of functional magnetic resonance imaging (fMRI) data in response to multisensory phenomena. Using event-related fMRI, we observed that simple auditory stimuli (noise bursts) activated primary visual cortices and that simple visual stimuli (checkerboards) activated primary auditory cortices, indicative of multisensory convergence. Moreover, analyses of blood oxygen level-dependent response dynamics revealed facilitation of hemodynamic response peak latencies and slopes for multisensory auditory-visual stimuli versus either unisensory condition, indicative of multisensory interactions within primary sensory cortices. Neural processing at the lowest cortical levels can be modulated by interactions between the senses. Temporal information in fMRI data can reveal these modulations and overcome analytic and interpretational challenges of more traditional procedures. In addition to providing an essential translational link with animal models, these results suggest that longstanding notions of cortical organization need to be revised to include multisensory interactions as an inherent component of functional brain organization.
Keywords
Acoustic Stimulation, Adult, Auditory Cortex, Auditory Perception, Blood Flow Velocity, Brain Mapping, Evoked Potentials, Auditory, Evoked Potentials, Visual, Female, Humans, Magnetic Resonance Imaging, Male, Oxygen, Photic Stimulation, Visual Cortex, Visual Perception
Pubmed
Web of science
Open Access
Yes
Create date
07/03/2008 9:34
Last modification date
25/09/2019 6:10
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