Combining immunotherapy and anticancer agents: the right path to achieve cancer cure?

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Serval ID
serval:BIB_B0FEEA6CE1BB
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Combining immunotherapy and anticancer agents: the right path to achieve cancer cure?
Journal
Annals of Oncology
Author(s)
Apetoh L., Ladoire S., Coukos G., Ghiringhelli F.
ISSN
1569-8041 (Electronic)
ISSN-L
0923-7534
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
26
Number
9
Pages
1813-1823
Language
english
Abstract
Recent clinical trials revealed the impressive efficacy of immunological checkpoint blockade in different types of metastatic cancers. Such data underscore that immunotherapy is one of the most promising strategies for cancer treatment. In addition, preclinical studies provide evidence that some cytotoxic drugs have the ability to stimulate the immune system, resulting in anti-tumor immune responses that contribute to clinical efficacy of these agents. These observations raise the hypothesis that the next step for cancer treatment is the combination of cytotoxic agents and immunotherapies. The present review aims to summarize the immune-mediated effects of chemotherapeutic agents and their clinical relevance, the biological and clinical features of immune checkpoint blockers and finally, the preclinical and clinical rationale for novel therapeutic strategies combining anticancer agents and immune checkpoint blockers.
Keywords
Antibodies, Monoclonal/therapeutic use, Antineoplastic Agents/therapeutic use, Combined Modality Therapy/methods, Humans, Immunotherapy/methods, Neoplasm Metastasis/immunology, Neoplasm Metastasis/prevention & control, Neoplasms/immunology, Neoplasms/therapy
Pubmed
Web of science
Open Access
Yes
Create date
19/06/2016 14:32
Last modification date
25/09/2019 6:10
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