Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder.
Details
Serval ID
serval:BIB_B0F3C01E6AD8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder.
Journal
American Journal of Human Genetics
ISSN
0002-9297 (Print)
ISSN-L
0002-9297
Publication state
Published
Issued date
2003
Volume
73
Number
2
Pages
370-376
Language
english
Abstract
We evaluated a possible association between the brain-derived neurotrophic factor (BDNF) gene and susceptibility to obsessive-compulsive disorder (OCD) by genotyping a number of single-nucleotide polymorphisms (SNPs) and one microsatellite marker from the extended BDNF locus in 164 triads with OCD. Extensive background linkage disequilibrium was observed at this locus. Single-locus transmission-distortion tests revealed significant evidence of association with the disease for all the BDNF gene markers tested, including a Val66Met variation affecting the sequence of the proBDNF protein. Analysis of multi-SNP haplotypes provided similar results. Haplotype transmission comparisons in this and previous studies point to a functionally distinct BDNF haplotype uniquely marked by the rare Met66 allele, which is undertransmitted and likely confers a protective effect in OCD and other psychiatric disorders.
Keywords
Adolescent, Adult, Age of Onset, Alleles, Brain-Derived Neurotrophic Factor/genetics, Child, Exons, Female, Genetic Variation, Genotype, Haplotypes, Humans, Introns, Linkage Disequilibrium, Male, Microsatellite Repeats, Obsessive-Compulsive Disorder/genetics, Polymorphism, Single Nucleotide, Protein Precursors/genetics
Pubmed
Open Access
Yes
Create date
27/02/2012 16:43
Last modification date
20/08/2019 15:19
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