Impact of Risk Factors on Short and Long-Term Maternal and Neonatal Outcomes in Women With Gestational Diabetes Mellitus: A Prospective Longitudinal Cohort Study.

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State: Public
Version: author
License: CC BY 4.0
Serval ID
serval:BIB_AF74FCC94ECC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Impact of Risk Factors on Short and Long-Term Maternal and Neonatal Outcomes in Women With Gestational Diabetes Mellitus: A Prospective Longitudinal Cohort Study.
Journal
Frontiers in endocrinology
Author(s)
Corcillo A., Quansah D.Y., Kosinski C., Benhalima K., Puder J.J.
ISSN
1664-2392 (Print)
ISSN-L
1664-2392
Publication state
Published
Issued date
2022
Peer-reviewed
Oui
Volume
13
Pages
866446
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Universal screening of gestational diabetes mellitus (GDM) in women with no risk factors (RF) for GDM remains controversial. This study identified the impact of the presence of RF on perinatal and postpartum outcomes.
This prospective cohort study included 780 women with GDM. GDM RF included previous GDM, first grade family history of type 2 diabetes, high-risk ethnicity and pre-pregnancy overweight/obesity (OW/OB). Outcomes included obstetrical, neonatal and maternal metabolic parameters during pregnancy and up to 1 year postpartum.
Out of 780 patients, 24% had no RF for GDM. Despite this, 40% of them needed medical treatment and they had a high prevalence of glucose intolerance of 21 and 27% at 6-8 weeks and 1-year postpartum, respectively. Despite similar treatment, women with RF had more neonatal and obstetrical complications, but they had especially more frequent adverse metabolic outcomes in the short- and long-term. The most important RF for poor perinatal outcome were previous GDM and pre-pregnancy OW/OB, whereas high-risk ethnicity and pre-pregnancy OW/OB were RF for adverse postpartum metabolic outcomes. Increasing number of RF were associated with worsened perinatal and long-term postpartum outcomes except for pregnancy-induced hypertension, C-section delivery and neonatal hypoglycaemia.
Women with no RF had a high prevalence of adverse perinatal and postpartum outcomes, while the presence of RF particularly increased the risk for postpartum adverse metabolic outcomes. This calls for a RF-based long-term follow-up of women with GDM.
Keywords
Cohort Studies, Diabetes Mellitus, Type 2/epidemiology, Diabetes Mellitus, Type 2/etiology, Diabetes, Gestational/diagnosis, Diabetes, Gestational/epidemiology, Diabetes, Gestational/etiology, Female, Humans, Infant, Newborn, Longitudinal Studies, Obesity/epidemiology, Pregnancy, Pregnancy Outcome/epidemiology, Prospective Studies, GDM, gestational diabetes, gestational diabetes mellitus, maternal outcomes, neonatal outcomes, risk factors
Pubmed
Open Access
Yes
Create date
19/07/2022 14:11
Last modification date
29/07/2022 6:39
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