Mediterranean diet and risk of endometrial cancer: a pooled analysis of three italian case-control studies.

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Version: Final published version
Serval ID
serval:BIB_AF671238D2FE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Mediterranean diet and risk of endometrial cancer: a pooled analysis of three italian case-control studies.
Journal
British Journal of Cancer
Author(s)
Filomeno M., Bosetti C., Bidoli E., Levi F., Serraino D., Montella M., La Vecchia C., Tavani A.
ISSN
1532-1827 (Electronic)
ISSN-L
0007-0920
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
112
Number
11
Pages
1816-1821
Language
english
Notes
IUMSP2015/05
Abstract
BACKGROUND: Some components of the Mediterranean diet have favourable effects on endometrial cancer, and the Mediterranean diet as a whole has been shown to have a beneficial role on various neoplasms.
METHODS: We analysed this issue pooling data from three case-control studies carried out between 1983 and 2006 in various Italian areas and in the Swiss Canton of Vaud. Cases were 1411 women with incident, histologically confirmed endometrial cancer, and controls were 3668 patients in hospital for acute diseases. We measured the adherence to the Mediterranean diet using a Mediterranean Diet Score (MDS), based on the nine dietary components characteristics of this diet, that is, high intake of vegetables, fruits/nuts, cereals, legumes, fish; low intake of dairy products and meat; high monounsaturated to saturated fatty acid ratio; and moderate alcohol intake. We estimated the odds ratios (OR) and the corresponding 95% confidence intervals (CI) for increasing levels of the MDS (varying from 0, no adherence, to 9, maximum adherence) using multiple logistic regression models, adjusted for major confounding factors.
RESULTS: The adjusted OR for a 6-9 components of the MDS (high adherence) compared with 0-3 (low adherence) was 0.43 (95% CI 0.34-0.56). The OR for an increment of one component of MDS diet was 0.84 (95% CI 0.80-0.88). The association was consistent in strata of various covariates, although somewhat stronger in older women, in never oral contraceptive users and in hormone-replacement therapy users.
CONCLUSIONS: Our study provides evidence for a beneficial role of the Mediterranean diet on endometrial cancer risk, suggesting a favourable effect of a combination of foods rich in antioxidants, fibres, phytochemicals, and unsaturated fatty acids.
Pubmed
Web of science
Open Access
Yes
Create date
04/06/2015 13:14
Last modification date
20/08/2019 15:18
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