Access to therapy and therapy outcomes in the Swiss Hepatitis C Cohort Study: a person-centred approach.

Details

Serval ID
serval:BIB_AF5AE3EFB723
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Access to therapy and therapy outcomes in the Swiss Hepatitis C Cohort Study: a person-centred approach.
Journal
Journal of viral hepatitis
Author(s)
Giudici F., Bertisch B., Negro F., Stirnimann G., Müllhaupt B., Moradpour D., Cerny A., Keiser O.
Working group(s)
Swiss Hepatitis C Cohort Study
Contributor(s)
Kaiser L., Heim M., Hirsch H., Dufour J.F., Gorgievski M., Aubert V., Siegrist H.H., Lucchini G.M., Malinverni R., Semela D., Schmid P., Dollenmaier G., Probst-Müller E., Fabbro T., Rudquist M., Benkert P.
ISSN
1365-2893 (Electronic)
ISSN-L
1352-0504
Publication state
Published
Issued date
09/2016
Peer-reviewed
Oui
Volume
23
Number
9
Pages
697-707
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Socio-demographic and behavioural characteristics are associated with delayed diagnosis and disease progression in HCV-infected persons. However, many analyses focused on single variables rather than groups defined by several variables. We used latent class analysis to study all 4488 persons enrolled in the Swiss Hepatitis C Cohort Study. Groups were identified using predefined variables at enrolment. The number of groups was selected using the Bayesian information criterion. Mortality, loss to follow-up, cirrhosis, treatment status and response to antivirals were analysed using Laplace and logistic regressions. We identified five groups and named them according to their characteristics: persons who inject drugs, male drinkers, Swiss employees, foreign employees and retirees. Two groups did not conform to common assumptions about persons with chronic hepatitis C and were already in an advanced stage of the disease at enrolment: 'male drinkers' and 'retirees' had a high proportion of cirrhosis at enrolment (15% and 16% vs <10.3%), and the shortest time to death (adjusted median time 8.7 years and 8.8 years vs >9.0). 'Male drinkers' also had high substance use, but they were well educated and were likely to be employed. This analysis may help identifying high-risk groups which may benefit from targeted interventions.

Keywords
Adolescent, Adult, Aged, Aged, 80 and over, Antiviral Agents/therapeutic use, Cohort Studies, Female, Health Services Accessibility, Hepatitis C, Chronic/drug therapy, Humans, Male, Middle Aged, Switzerland, Treatment Outcome, Young Adult, alcohol, hepatitis C, latent class analysis, persons who inject drugs, socio-behaviour
Pubmed
Web of science
Create date
29/03/2016 11:49
Last modification date
20/08/2019 15:18
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