Stimulation of thermogenesis in men after combined glucose-long-chain triglyceride infusion.

Details

Serval ID
serval:BIB_AF3807914DBA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Stimulation of thermogenesis in men after combined glucose-long-chain triglyceride infusion.
Journal
American Journal of Clinical Nutrition
Author(s)
Thiebaud D., Acheson K., Schutz Y., Felber J.P., Golay A., Defronzo R.A., Jéquier E.
ISSN
0002-9165 (Print)
ISSN-L
0002-9165
Publication state
Published
Issued date
1983
Volume
37
Number
4
Pages
603-611
Language
english
Abstract
The effect of combined long-chain triglyceride infusion (Intralipid 20%) with graded doses of insulin/glucose on energy expenditure was examined in 17 healthy young male volunteers by using the euglycemic insulin clamp technique in combination with indirect calorimetry. Intralipid was infused for 90 min at a constant rate of 0.23 g/min; plasma free fatty acids increased from base-line values of 380 +/- 8 mumol/l to steady state levels of 650 +/- 12 mumol/l. After 90 min the Intralipid was continued and insulin was infused at three rates (0.5, 2, and 4 mU/kg . min) to achieve steady state hyperinsulinemic plateaus of 63 +/- 4, 167 +/- 10, and 410 +/- 15 microU/ml. Plasma glucose concentration was maintained constant at basal euglycemic levels (insulin clamp technique) by infusing glucose at 0.24, 0.48, and 0.59 g/min, respectively. Glucose storage during the insulin clamp (ie, glucose uptake minus glucose oxidation) was 0.13, 0.33, and 0.40 g/min for each group and exogenous lipid storage was 0.17, 0.18, and 0.19 g/min, respectively. The net increment in energy expenditure was 0.15, 0.24, and 0.26 kcal/min, respectively, which represents 8.5% of the energy content of the total amount of glucose and lipid stored. The experimentally determined value (approximately 9%) for the cost of storing both glucose and lipid was found to be significantly greater than predicted by stoichiometric calculations. However, the experimental value for the combined infusion was less than that observed for glucose storage alone (12%). This finding provides support for the use of combined glucose/fat infusions in parenteral nutrition as it is used more economically than when glucose is infused alone.
Keywords
Adult, Blood Glucose/metabolism, Body Temperature Regulation/drug effects, Calorimetry, Indirect, Dose-Response Relationship, Drug, Energy Metabolism/drug effects, Fat Emulsions, Intravenous/administration & dosage, Glucose/administration & dosage, Humans, Infusions, Parenteral, Insulin/administration & dosage, Insulin/blood, Lipids/blood, Male
Pubmed
Web of science
Create date
21/01/2008 13:08
Last modification date
20/08/2019 15:18
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