Cardiac Toxicity in Selective Serotonin Reuptake Inhibitor Users.

Details

Serval ID
serval:BIB_AEFD791D264D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cardiac Toxicity in Selective Serotonin Reuptake Inhibitor Users.
Journal
American Journal of Forensic Medicine and Pathology
Author(s)
Lusetti M., Licata M., Silingardi E., Reggiani Bonetti L., Palmiere C.
ISSN
1533-404X (Electronic)
ISSN-L
0195-7910
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
36
Number
4
Pages
293-297
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Several classes of recreational and prescription drugs have been associated with an increased risk of cardiovascular disease and the occurrence of arrhythmias, which may be involved in sudden deaths in chronic users even at therapeutic doses. The study presented herein focuses on pathological changes involving the heart, which may be caused by selective serotonin reuptake inhibitor use and their possible role in the occurrence of sudden cardiac death. A total of 40 cases were included in the study and were divided evenly into 2 groups: 20 cases of patients treated with selective serotonin reuptake inhibitors and 20 cases of sudden deaths involving patients void of any drug treatment. The first group included 16 patients treated with citalopram and 4 with sertraline. Autopsies, histology, biochemistry, and toxicology were performed in all cases. Pathological changes in selective serotonin reuptake inhibitor users consisted of various degrees of interstitial and perivascular fibrosis as well as a small degree of perineural fibrosis within the myocardium of the left ventricle. Within the limits of the small number of investigated cases, the results of this study seem to confirm former observations on this topic, suggesting that selective serotonin reuptake inhibitors may play a potential, causative role in the pathogenesis of sudden deaths in chronic users even at therapeutic concentrations.
Keywords
Case-Control Studies, Citalopram/adverse effects, Female, Fibrosis, Humans, Male, Middle Aged, Myocardium/pathology, Myocytes, Cardiac/pathology, Retrospective Studies, Serotonin Uptake Inhibitors/adverse effects, Sertraline/adverse effects
Pubmed
Web of science
Create date
13/10/2015 8:41
Last modification date
20/08/2019 15:18
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