Ig allotype-linked regulation of class and subclass composition of natural antibodies to group A streptococcal carbohydrate.

Details

Serval ID
serval:BIB_AEF8F0EDBFAF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Ig allotype-linked regulation of class and subclass composition of natural antibodies to group A streptococcal carbohydrate.
Journal
Journal of immunology (Baltimore, Md. : 1950)
Author(s)
Morell A., Vassalli G., DeLange G.G., Skvaril F., Ambrosino D.M., Siber G.R.
ISSN
0022-1767 (Print)
ISSN-L
0022-1767
Publication state
Published
Issued date
01/04/1989
Peer-reviewed
Oui
Volume
142
Number
7
Pages
2495-2500
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Abstract
To determine the importance of genes located in or near the Ig constant regions in regulating the human antibody response, we correlated Ig allotypic markers with total Ig concentrations and natural antibody concentrations to the streptococcal group A carbohydrate (A-CHO) in 193 healthy adult blood donors. The major correlations between Ig allotypes and total Ig and specific antibody concentrations were observed with the Gm(f;n;b) haplotype. When compared with Gm(f;n;b) negative individuals, Gm(f;n;b) positives had significantly higher concentrations of total IgG2 (p less than 0.001) and IgG2 anti A-CHO (p less than 0.05), lower concentrations of total IgG1 (p less than 0.001) and IgG1 anti A-CHO (p less than 0.001), and lower concentrations of total IgM (p less than 0.001) and IgM anti A-CHO (p less than 0.05). We conclude that individuals with the Gm(f;n;b) haplotype respond preferentially with IgG2 rather than IgG1 subclass antibodies. This increased capacity to respond with IgG2 antibodies may be reflected in the magnitude of the total antibody response when the IgG2 subclass comprises a major proportion of the response, as occurs in the adult response to many polysaccharide Ag.

Keywords
Adult, Antibodies, Bacterial/analysis, Antibodies, Bacterial/classification, Antibody Specificity, Humans, Immunoglobulin Allotypes/analysis, Immunoglobulin Allotypes/physiology, Immunoglobulin G/analysis, Immunoglobulin Gm Allotypes/analysis, Immunoglobulin M/analysis, Male, Polysaccharides, Bacterial/immunology, Streptococcus pyogenes/immunology
Pubmed
Create date
15/12/2016 13:35
Last modification date
20/08/2019 15:18
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