Colonisation with Pseudomonas aeruginosa and antibiotic resistance patterns in COPD patients

Details

Serval ID
serval:BIB_AEDD168FE573
Type
Article: article from journal or magazin.
Collection
Publications
Title
Colonisation with Pseudomonas aeruginosa and antibiotic resistance patterns in COPD patients
Journal
Swiss Med Wkly
Author(s)
Engler K., Muhlemann K., Garzoni C., Pfahler H., Geiser T., von Garnier C.
ISSN
1424-3997 (Electronic)
ISSN-L
0036-7672
Publication state
Published
Issued date
2012
Volume
142
Pages
w13509
Language
english
Notes
Engler, Kathrin
Muhlemann, Kathrin
Garzoni, Christian
Pfahler, Henrik
Geiser, Thomas
von Garnier, Christophe
eng
Comparative Study
Switzerland
Swiss Med Wkly. 2012 Jan 30;142:w13509. doi: 10.4414/smw.2012.13509. eCollection 2012.
Abstract
QUESTIONS: P. aeruginosa infections are assumed to play a major role in the frequency of exacerbations and severity of chronic obstructive pulmonary disease (COPD). Colonisation with P. aeruginosa accelerates lung function decline, most probably due to more frequent exacerbations. In this retrospective study we aimed to determine the prevalence of colonisation with P. aeruginosa in COPD patients treated in a tertiary hospital centre. METHODS: 112 patients diagnosed with COPD testing positive for P. aeruginosa in at least one respiratory sample during the study period (2004-2008) were retrospectively analysed to estimate GOLD stage-specific prevalences, colonisation patterns, morphology and antibiotic resistance profiles of P. aeruginosa strains. RESULTS: Colonisation with P. aeruginosa was present in all COPD stages, but prevalence significantly increased with disease severity (GOLD 1: 0.7%, GOLD 2: 1.5%; GOLD 3: 1.5%; GOLD 4: 2.6%; p = 0.0003). 41% of COPD patients with P. aeruginosa-positive respiratory samples were chronic carriers, of whom 8% had mucoid strains. Carriage of a mucoid strain was associated with advanced COPD stage GOLD 4 (p = 0.01). Resistance to cephalosporins was most frequently encountered and resistance to ciprofloxacin was found in more advanced stages of COPD. CONCLUSIONS: Colonisation with P. aeruginosa was present in all COPD severity stages and colonisation with mucoid strains was more frequent in advanced COPD. Resistance to the only oral anti-pseudomonas antibiotic ciprofloxacin was more frequently encountered in severe COPD stages.
Keywords
Aged, Anti-Bacterial Agents/*therapeutic use, Colony Count, Microbial, *Drug Resistance, Bacterial, Female, Follow-Up Studies, Humans, Male, Prevalence, Pseudomonas Infections/complications/*drug therapy/epidemiology, Pseudomonas aeruginosa/drug effects/*growth & development/isolation &, purification, Pulmonary Disease, Chronic Obstructive/*complications/microbiology, Retrospective Studies, Sputum/*microbiology, Switzerland/epidemiology
Pubmed
Create date
15/04/2021 10:58
Last modification date
01/05/2021 6:33
Usage data