Superior hemodynamics in left heart bypass without systemic heparinization

Details

Serval ID
serval:BIB_AED0DDB2BA1A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Superior hemodynamics in left heart bypass without systemic heparinization
Journal
European Journal of Cardio-Thoracic Surgery
Author(s)
von Segesser  L. K., Weiss  B. M., Gallino  A., Leskosek  B., Redha  F., von Felten  A., Turina  M.
ISSN
1010-7940
Publication state
Published
Issued date
1990
Peer-reviewed
Oui
Volume
4
Number
7
Pages
384-8; discussion 389
Notes
Journal Article
Research Support, Non-U.S. Gov't
Abstract
Open-chest left heart bypass was performed in 10 canine experiments (30 +/- 9 kg) by a servo controlled roller pump for 6 h at a pump flow of 50 ml/min per kg bodyweight. The surfaces of the tubing sets were either standard (with systemic heparinization) or with end-point attached heparin (no systemic heparin). Besides continuous monitoring of hemodynamics, a standard battery of blood samples was taken before bypass, after 10 min and every hour thereafter. There is no evidence of increased fibrin production in the group with end-point attached heparin surfaces perfused without systemic heparinization. Superior hemodynamics in left heart bypass performed without systemic heparinization appear to be due to improved hemostasis, reduced blood loss and therefore reduced transfusion requirements. Left heart bypass with heparin-coated equipment has been successfully used for resection of a thoracoabdominal aneurysm in six patients.
Keywords
Animals Blood Platelets/analysis Cardiopulmonary Bypass/instrumentation/*methods/standards Dogs Fibrin/analysis Heart Rate Hematocrit *Hemodynamics Heparin/administration & dosage/*therapeutic use Monitoring, Physiologic Whole Blood Coagulation Time
Pubmed
Web of science
Create date
14/02/2008 14:17
Last modification date
20/08/2019 15:18
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