Medication use in pregnancy: a cross-sectional, multinational web-based study.

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State: Public
Version: Final published version
Serval ID
serval:BIB_AEA5D76112F5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Medication use in pregnancy: a cross-sectional, multinational web-based study.
Journal
Bmj Open
Author(s)
Lupattelli A., Spigset O., Twigg M.J., Zagorodnikova K., Mårdby A.C., Moretti M.E., Drozd M., Panchaud A., Hämeen-Anttila K., Rieutord A., Gjergja Juraski R., Odalovic M., Kennedy D., Rudolf G., Juch H., Passier A., Björnsdóttir I., Nordeng H.
ISSN
2044-6055 (Electronic)
Publication state
Published
Issued date
02/2014
Volume
4
Number
2
Pages
e004365
Language
english
Notes
Publication types: Journal Article Publication Status: epublish
Abstract
OBJECTIVES: Intercountry comparability between studies on medication use in pregnancy is difficult due to dissimilarities in study design and methodology. This study aimed to examine patterns and factors associated with medications use in pregnancy from a multinational perspective, with emphasis on type of medication utilised and indication for use.
DESIGN: Cross-sectional, web-based study performed within the period from 1 October 2011 to 29 February 2012. Uniform collection of drug utilisation data was performed via an anonymous online questionnaire.
SETTING: Multinational study in Europe (Western, Northern and Eastern), North and South America and Australia.
PARTICIPANTS: Pregnant women and new mothers with children less than 1 year of age.
PRIMARY AND SECONDARY OUTCOME MEASURES: Prevalence of and factors associated with medication use for acute/short-term illnesses, chronic/long-term disorders and over-the-counter (OTC) medication use.
RESULTS: The study population included 9459 women, of which 81.2% reported use of at least one medication (prescribed or OTC) during pregnancy. Overall, OTC medication use occurred in 66.9% of the pregnancies, whereas 68.4% and 17% of women reported use of at least one medication for treatment of acute/short-term illnesses and chronic/long-term disorders, respectively. The extent of self-reported medicated illnesses and types of medication used by indication varied across regions, especially in relation to urinary tract infections, depression or OTC nasal sprays. Women with higher age or lower educational level, housewives or women with an unplanned pregnancy were those most often reporting use of medication for chronic/long-term disorders. Immigrant women in Western (adjusted OR (aOR): 0.55, 95% CI 0.34 to 0.87) and Northern Europe (aOR: 0.50, 95% CI 0.31 to 0.83) were less likely to report use of medication for chronic/long-term disorders during pregnancy than non-immigrants.
CONCLUSIONS: In this study, the majority of women in Europe, North America, South America and Australia used at least one medication during pregnancy. There was a substantial inter-region variability in the types of medication used.
Pubmed
Web of science
Open Access
Yes
Create date
11/03/2014 16:28
Last modification date
20/08/2019 16:18
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