Systems medicine approaches for the definition of complex phenotypes in chronic diseases and ageing. From concept to implementation and policies


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Systems medicine approaches for the definition of complex phenotypes in chronic diseases and ageing. From concept to implementation and policies
Curr Pharm Des
Bousquet J., Jorgensen C., Dauzat M., Cesario A., Camuzat T., Bourret R., Best N., Anto J. M., Abecassis F., Aubas P., Avignon A., Badin M., Bedbrook A., Blain H., Bourdin A., Bringer J., Camu W., Cayla G., Costa D. J., Courtet P., Cristol J. P., Demoly P., de la Coussaye J. E., Fesler P., Gouzi F., Gris J. C., Guillot B., Hayot M., Jeandel C., Jonquet O., Journot L., Lehmann S., Mathieu G., Morel J., Ninot G., Pelissier J., Picot M. C., Radier-Pontal F., Robine J. M., Rodier M., Roubille F., Sultan A., Wojtusciszyn A., Auffray C., Balling R., Barbara C., Cambon-Thomsen A., Chavannes N. H., Chuchalin A., Crooks G., Dedeu A., Fabbri L. M., Garcia-Aymerich J., Hajjam J., Melo Gomes E., Palkonen S., Piette F., Pison C., Price D., Samolinski B., Schunemann H. J., Sterk P. J., Yiallouros P., Roca J., Van de Perre P., Mercier J.
1873-4286 (Electronic)
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Bousquet, Jean
Jorgensen, Christian
Dauzat, Michel
Cesario, Alfredo
Camuzat, Thierry
Bourret, Rodolphe
Best, Nicolas
Anto, Josep M
Abecassis, Frederic
Aubas, Pierre
Avignon, Antoine
Badin, Melanie
Bedbrook, Anna
Blain, Hubert
Bourdin, Arnaud
Bringer, Jacques
Camu, William
Cayla, Guilhaume
Costa, David J
Courtet, Philippe
Cristol, Jean-Paul
Demoly, Pascal
de la Coussaye, Jean-Emmanuel
Fesler, Pierre
Gouzi, Fares
Gris, Jean-Christophe
Guillot, Bernard
Hayot, Maurice
Jeandel, Claude
Jonquet, Olivier
Journot, Laurent
Lehmann, Sylvain
Mathieu, Gwenaelle
Morel, Jacques
Ninot, Gregory
Pelissier, Jacques
Picot, Marie-Christine
Radier-Pontal, Francoise
Robine, Jean-Marie
Rodier, Michel
Roubille, Francois
Sultan, Ariane
Wojtusciszyn, Anne
Auffray, Charles
Balling, Rudi
Barbara, Cristina
Cambon-Thomsen, Anne
Chavannes, Niels H
Chuchalin, Alexander
Crooks, George
Dedeu, Antoni
Fabbri, Leonardo M
Garcia-Aymerich, Judith
Hajjam, Jawad
Melo Gomes, Elisabete
Palkonen, Susana
Piette, Francois
Pison, Christophe
Price, David
Samolinski, Boleslaw
Schunemann, Holger J
Sterk, Peter J
Yiallouros, Panayiotis
Roca, Josep
Van de Perre, Philippe
Mercier, Jacques
Research Support, Non-U.S. Gov't
United Arab Emirates
Curr Pharm Des. 2014;20(38):5928-44. doi: 10.2174/1381612820666140314115505.
Chronic diseases are diseases of long duration and slow progression. Major NCDs (cardiovascular diseases, cancer, chronic respiratory diseases, diabetes, rheumatologic diseases and mental health) represent the predominant health problem of the Century. The prevention and control of NCDs are the priority of the World Health Organization 2008 Action Plan, the United Nations 2010 Resolution and the European Union 2010 Council. The novel trend for the management of NCDs is evolving towards integrative, holistic approaches. NCDs are intertwined with ageing. The European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) has prioritised NCDs. To tackle them in their totality in order to reduce their burden and societal impact, it is proposed that NCDs should be considered as a single expression of disease with different risk factors and entities. An innovative integrated health system built around systems medicine and strategic partnerships is proposed to combat NCDs. It includes (i) understanding the social, economic, environmental, genetic determinants, as well as the molecular and cellular mechanisms underlying NCDs; (ii) primary care and practice-based interprofessional collaboration; (iii) carefully phenotyped patients; (iv) development of unbiased and accurate biomarkers for comorbidities, severity and follow up of patients; (v) socio-economic science; (vi) development of guidelines; (vii) training; and (viii) policy decisions. The results could be applicable to all countries and adapted to local needs, economy and health systems. This paper reviews the complexity of NCDs intertwined with ageing. It gives an overview of the problem and proposes two practical examples of systems medicine (MeDALL) applied to allergy and to NCD co-morbidities (MACVIA-LR, Reference Site of the European Innovation Partnership on Active and Healthy Ageing).
Aging/*pathology/physiology, Cardiovascular Diseases/epidemiology/therapy, Chronic Disease, Comorbidity, Delivery of Health Care, Integrated/*methods/trends, Health Policy/trends, Humans, Neoplasms/epidemiology/therapy, *Phenotype
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14/06/2021 9:58
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18/09/2021 6:38
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