Serotonin-producing enterochromaffin cell tumors of the pancreas: clinicopathologic study of 15 cases and comparison with intestinal enterochromaffin cell tumors.

Details

Serval ID
serval:BIB_AE56F4192310
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Serotonin-producing enterochromaffin cell tumors of the pancreas: clinicopathologic study of 15 cases and comparison with intestinal enterochromaffin cell tumors.
Journal
Pancreas
Author(s)
La Rosa S., Franzi F., Albarello L., Schmitt A., Bernasconi B., Tibiletti M.G., Finzi G., Placidi C., Perren A., Capella C.
ISSN
1536-4828 (Electronic)
ISSN-L
0885-3177
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
40
Number
6
Pages
883-895
Language
english
Notes
Publication types: Case Reports ; Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Abstract
OBJECTIVES: Serotonin-producing tumors of the pancreas are rare endocrine neoplasms composed of enterochromaffin (EC) cells that have been mainly described in the literature as case reports. This study analyzes the clinicopathologic features of a series of pancreatic EC cell neoplasms and their similarities to and differences from intestinal EC cell tumors.
METHODS: The morphological, immunohistochemical, ultrastructural, and fluorescent in situ hybridization features of 15 pancreatic and 20 intestinal serotonin-producing neoplasms were compared. In addition, we reviewed the literature on pancreatic serotonin-producing tumors to better understand the clinicopathologic features of this rare tumor type.
RESULTS: The lack of substance P and acidic fibroblast growth factor immunoreactivity; the low immunohistochemical expression of CDX2, vesicular monoamine transporter 1, connective tissue growth factor, and prostatic acid phosphatase; the lack of S100-positive sustentacular cells; the strong expression of vesicular monoamine transporter 2; and peculiar ultrastructural features characterize pancreatic EC cell tumors and differentiate them from intestinal ones, although both categories show similar chromosome 18 cytogenetic alterations. The review of the literature indicates that pancreatic functioning tumors associated with the carcinoid syndrome arise in younger patients and are larger, more frequently malignant, and more aggressive neoplasms than pancreatic nonfunctioning ones.
CONCLUSIONS: Pancreatic EC cell tumors show several different morphological features compared with related intestinal tumors despite similar cytogenetic alterations on chromosome 18.
Keywords
Adult, Aged, Carcinoid Tumor/metabolism, Carcinoid Tumor/pathology, Chromosomes, Human, Pair 18/genetics, Enterochromaffin Cells/metabolism, Enterochromaffin Cells/pathology, Female, Humans, In Situ Hybridization, Fluorescence, Intestinal Neoplasms/genetics, Intestinal Neoplasms/metabolism, Kaplan-Meier Estimate, Male, Malignant Carcinoid Syndrome/genetics, Malignant Carcinoid Syndrome/metabolism, Microscopy, Electron, Transmission, Middle Aged, Pancreatic Neoplasms/genetics, Pancreatic Neoplasms/metabolism, Serotonin/biosynthesis
Pubmed
Web of science
Create date
06/09/2016 13:23
Last modification date
20/08/2019 15:18
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