A chemical shift encoding (CSE) approach for spectral selection in fluorine-19 MRI.

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State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_ADDE04BB4CA5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A chemical shift encoding (CSE) approach for spectral selection in fluorine-19 MRI.
Journal
Magnetic resonance in medicine
Author(s)
Ludwig K.D., Hernando D., Roberts N.T., van Heeswijk R.B., Fain S.B.
ISSN
1522-2594 (Electronic)
ISSN-L
0740-3194
Publication state
Published
Issued date
04/2018
Peer-reviewed
Oui
Volume
79
Number
4
Pages
2183-2189
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
To develop a chemical shift encoding (CSE) approach for fluorine-19 MRI of perfluorocarbons in the presence of multiple known fluorinated chemical species.
A multi-echo CSE technique is applied for spectral separation of the perfluorocarbon perfluoro-15-crown-5-ether (PFCE) and isoflurane (ISO) based on their chemical shifts at 4.7 T. Cramér-Rao lower bound analysis is used to identify echo combinations with optimal signal-to-noise performance. Signal contributions are fit with a multispectral fluorine signal model using a non-linear least squares estimation reconstruction directly from k-space data. This CSE approach is tested in fluorine-19 phantoms and in a mouse with a 2D and 3D spoiled gradient-echo acquisition using multiple echo times determined from Cramér-Rao lower bound analysis.
Cramér-Rao lower bound analysis for PFCE and ISO separation shows signal-to-noise performance is maximized with a 0.33 ms echo separation. A linear behavior (R <sup>2</sup>  = 0.987) between PFCE signal and known relative PFCE volume is observed in CSE reconstructed images using a mixed PFCE/ISO phantom. Effective spatial and spectral separation of PFCE and ISO is shown in phantoms and in vivo.
Feasibility of a gradient-echo CSE acquisition and image reconstruction approach with optimized noise performance is demonstrated through fluorine-19 MRI of PFCE with effective removal of ISO signal contributions. Magn Reson Med 79:2183-2189, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Keywords
Animals, Computer Simulation, Contrast Media/chemistry, Crown Ethers/chemistry, Fluorine-19 Magnetic Resonance Imaging, Humans, Image Processing, Computer-Assisted/methods, Isoflurane/chemistry, Linear Models, Magnetic Resonance Imaging, Male, Mice, Mice, Inbred C57BL, Models, Statistical, Phantoms, Imaging, Signal-To-Noise Ratio, chemical shift encoding, fluorine-19, magnetic resonance imaging
Pubmed
Web of science
Create date
15/11/2017 14:44
Last modification date
20/08/2019 16:17
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