Pancreatic adenocarcinoma with histologically proven portal vein infiltration: what is the outcome?

Details

Serval ID
serval:BIB_AD9AFF49453D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Pancreatic adenocarcinoma with histologically proven portal vein infiltration: what is the outcome?
Journal
European journal of gastroenterology & hepatology
Author(s)
Martin D., Petermann D., Fontanella S., Pu Y., Halkic N., Demartines N., Schäfer M.
ISSN
1473-5687 (Electronic)
ISSN-L
0954-691X
Publication state
Published
Issued date
12/2018
Peer-reviewed
Oui
Volume
30
Number
12
Pages
1507-1513
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Technical feasibility and safety of portal vein (PV) and superior mesenteric vein (SMV) resection during pancreaticoduodenectomy (PD) for cancer has been confirmed, but oncological benefits remain unclear. The present study aimed to explore the long-term outcomes of PD with PV/SMV resection and proven histologically invasion.
A total of 95 consecutive PD were performed between January 2008 and August 2013, and 29 patients underwent PV/SMV resection with histologically proven venous tumor infiltration. Patients were matched 1 : 1 to controls who did not undergo venous resection, based on demographic and tumor characteristics.
Disease-free survival (DFS) of the PV/SMV invasion group and control group was 9.5 and 7.6 months, respectively (P=0.51). Median survival and survival at 1, 3, and 5 years were 12.9 months, 59, 17, and 10%, respectively, in case of PV/SMV invasion compared with 20.3 months, 72, 31, and 10%, respectively in control group (P=0.13). Patients with complete transmural infiltration presented nonsignificantly shorter DFS (9.0 months) compared with those with partial venous wall infiltration (18.4 months, P=0.78).
Histologically proven portal venous invasion in patients undergoing PD for adenocarcinoma seemed not to have an effect on both DFS and overall long-term survival.
Keywords
Aged, Carcinoma, Pancreatic Ductal/pathology, Carcinoma, Pancreatic Ductal/secondary, Carcinoma, Pancreatic Ductal/surgery, Female, Humans, Kaplan-Meier Estimate, Male, Mesenteric Veins/pathology, Mesenteric Veins/surgery, Middle Aged, Neoplasm Invasiveness, Neoplasm Recurrence, Local, Pancreatic Neoplasms/pathology, Pancreatic Neoplasms/surgery, Pancreaticoduodenectomy/adverse effects, Pancreaticoduodenectomy/methods, Portal Vein/pathology, Portal Vein/surgery, Postoperative Complications, Treatment Outcome
Pubmed
Web of science
Create date
19/09/2018 15:50
Last modification date
20/08/2019 16:17
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