Adducin polymorphism affects renal proximal tubule reabsorption in hypertension

Details

Serval ID
serval:BIB_AD8AE61ADFDA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Adducin polymorphism affects renal proximal tubule reabsorption in hypertension
Journal
Hypertension
Author(s)
Manunta  P., Burnier  M., D'Amico  M., Buzzi  L., Maillard  M., Barlassina  C., Lanella  G., Cusi  D., Bianchi  G.
ISSN
0194-911X (Print)
Publication state
Published
Issued date
02/1999
Volume
33
Number
2
Pages
694-7
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb
Abstract
Abnormalities in renal sodium reabsorption may be involved in the development and maintenance of experimental and clinical hypertension. Adducin polymorphism is thought to regulate ion transport in the renal tubule. It has recently been shown that there is a significant linkage of alpha-adducin locus to essential hypertension and that the 460Trp allele is associated with hypertension. Patients with this allele display larger blood pressure changes with body sodium variation. The aim of this study was to test whether alpha-adducin polymorphism is involved in abnormalities of renal function. Because proximal tubular reabsorption has been shown to be tightly coupled to renal perfusion pressure, this segmental tubular function was investigated in 54 (29 Gly/Gly and 25 Gly/Trp) untreated hypertensive patients in basal conditions with the use of endogenous lithium concentration and uric acid. Fractional excretions of lithium and uric acid were significantly decreased in the Gly/Trp hypertensive patients compared with the Gly/Gly hypertensives. The contribution of alpha-adducin to fractional excretion of lithium was investigated by multiple regression analysis. Adducin genotype was significantly (R2=0.11, F=6.5; P<0.01) and directly related to fraction excretion of lithium; gender, age, urinary Na+, urinary uric acid, mean blood pressure, and plasma renin activity were not related. In conclusion, the adducin gene can be considered to be a 'renal hypertensive gene' that modulates the capacity of tubular epithelial cells to transport Na+ and hence contributes to the level of blood pressure.
Keywords
Adult Calmodulin-Binding Proteins/*genetics Cytoskeletal Proteins/genetics Female Humans Hypertension/*genetics/physiopathology Kidney Concentrating Ability/*genetics Kidney Tubules, Proximal/*physiopathology Male Polymorphism, Genetic
Pubmed
Web of science
Create date
25/01/2008 13:59
Last modification date
20/08/2019 16:17
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