Physiological distribution of <sup>18</sup>F-FDG in the spinal cord: A systematic review.

Details

Serval ID
serval:BIB_AD5BCC9D5369
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Physiological distribution of <sup>18</sup>F-FDG in the spinal cord: A systematic review.
Journal
The journal of spinal cord medicine
Author(s)
Kiamanesh Z., Banezhad F., Nasiri Z., Emami F., Treglia G., Sadeghi R.
ISSN
2045-7723 (Electronic)
ISSN-L
1079-0268
Publication state
In Press
Peer-reviewed
Oui
Pages
1-8
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Context: The importance of physiologic distribution of <sup>18</sup> F-FDG in the spinal cord.Objective: The recognition of the physiologic distribution of <sup>18</sup> F-FDG in the spinal cord is pivotal for accurate PET/CT imaging interpretation, especially in oncologic patients. Therefore, we performed a systematic review to investigate the normal distribution of <sup>18</sup> F-FDG throughout the spinal cord.Methods: Data sources: We carried out a comprehensive search of the literature on the physiologic patterns of <sup>18</sup> F-FDG distribution in the spinal cord. PubMed and Scopus databases were searched using the following keywords: "spinal cord" AND "FDG". Data extraction: Findings of the selected articles were described.Results: Thirteen studies comprising 24,125 patients entered the systematic review. These investigations showed discrepancies in location, size, number, and intensity of <sup>18</sup> F-FDG uptake throughout the spinal cord. However, cumulative results showed that <sup>18</sup> F-FDG uptake was higher in the lower thoracic portion of spinal cord (T11-T12). Moreover, a decreasing trend in <sup>18</sup> F-FDG uptake was observed from cervical to lumbar levels. Low maximal standardized uptake values, female sex, and higher body weight seem to be related to the physiological spinal cord <sup>18</sup> F-FDG uptake.Conclusions: On <sup>18</sup> F-FDG PET/CT imaging, focal hypermetabolism of the spinal cord at the level of lower thoracic and lower cervical vertebrae should be considered physiological until proven otherwise.
Keywords
18F-FDG, PET, Physiological uptake, Positron emission tomography, Spinal cord, Spine
Pubmed
Web of science
Create date
07/11/2019 23:50
Last modification date
12/03/2020 7:26
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