Influence of Helicobacter pylori infection during atherogenesis in vivo in mice

Details

Serval ID
serval:BIB_AD314C248ABC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Influence of Helicobacter pylori infection during atherogenesis in vivo in mice
Journal
Circulation Research
Author(s)
Mach  F., Sukhova  G. K., Michetti  M., Libby  P., Michetti  P.
ISSN
1524-4571 (Electronic)
Publication state
Published
Issued date
01/2002
Volume
90
Number
1
Pages
E1-4
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Jan 11
Abstract
Inflammatory diseases may have a role in the pathogenesis of atherosclerosis. Several epidemiological and clinical studies have explored the possible association between Helicobacter pylori seropositivity, cardiovascular risk factors, and ischemic heart disease. The contradictory results of these studies have fueled a debate regarding the link between H pylori infection and atherogenesis. This study tested the hypothesis that H pylori infection might influence atherosclerosis in vivo in mice. Male wild-type C57/Bl6 mice and LDL-receptor deficient congenic mice were randomly assigned for infection with H pylori. All animals were fed a high-cholesterol diet (1.25%) for 6 or 12 weeks. At autopsy, we compared aortic atherosclerotic lesion formation and lipid deposition. H pylori infection influenced neither the progression of atherosclerotic lesions nor lipid deposition. Moreover, the cellularity of atherosclerotic lesions (macrophages and T cells) did not differ between mice infected or not infected with H pylori. This in vivo study performed in a mouse model of atherosclerosis revealed no indication that H pylori infection might contribute to the development of atherosclerotic lesion formation. The full text of this article is available at http://www.circresaha.org.
Keywords
Animals Aorta/metabolism/pathology Arteriosclerosis/etiology/genetics/*microbiology Cholesterol/blood Cholesterol, Dietary/administration & dosage Fibrinogen/metabolism Helicobacter Infections/*microbiology *Helicobacter pylori Lipids/blood Male Mice Mice, Inbred C57BL Mice, Knockout Receptors, LDL/deficiency/genetics
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 16:02
Last modification date
20/08/2019 15:17
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