The role of oxidative stress during inflammatory processes.

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Serval ID
serval:BIB_AD2736DEB8DF
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The role of oxidative stress during inflammatory processes.
Journal
Biological Chemistry
Author(s)
Lugrin J., Rosenblatt-Velin N., Parapanov R., Liaudet L.
ISSN
1437-4315 (Electronic)
ISSN-L
1431-6730
Publication state
Published
Issued date
2014
Volume
395
Number
2
Pages
203-230
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublishDocument Type: Review
Abstract
Abstract The production of various reactive oxidant species in excess of endogenous antioxidant defense mechanisms promotes the development of a state of oxidative stress, with significant biological consequences. In recent years, evidence has emerged that oxidative stress plays a crucial role in the development and perpetuation of inflammation, and thus contributes to the pathophysiology of a number of debilitating illnesses, such as cardiovascular diseases, diabetes, cancer, or neurodegenerative processes. Oxidants affect all stages of the inflammatory response, including the release by damaged tissues of molecules acting as endogenous danger signals, their sensing by innate immune receptors from the Toll-like (TLRs) and the NOD-like (NLRs) families, and the activation of signaling pathways initiating the adaptive cellular response to such signals. In this article, after summarizing the basic aspects of redox biology and inflammation, we review in detail the current knowledge on the fundamental connections between oxidative stress and inflammatory processes, with a special emphasis on the danger molecule high-mobility group box-1, the TLRs, the NLRP-3 receptor, and the inflammasome, as well as the transcription factor nuclear factor-κB.
Pubmed
Web of science
Open Access
Yes
Create date
19/02/2014 18:26
Last modification date
25/09/2019 6:10
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