The nature of the decrease in blood-cerebrospinal fluid barrier exchange during postnatal brain development in the rat.

Details

Serval ID
serval:BIB_ACC3BF157F2D
Type
Article: article from journal or magazin.
Collection
Publications
Title
The nature of the decrease in blood-cerebrospinal fluid barrier exchange during postnatal brain development in the rat.
Journal
Journal of Physiology
Author(s)
Habgood M.D., Knott G.W., Dziegielewska K.M., Saunders N.R.
ISSN
0022-3751 (Print)
ISSN-L
0022-3751
Publication state
Published
Issued date
08/1993
Peer-reviewed
Oui
Volume
468
Pages
73-83
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
1. The blood-cerebrospinal fluid (CSF) exchange of a wide range of passively transported lipid insoluble compounds (0.43-5.4 nm molecular radius) has been investigated in rats at different stages of postnatal development (2 days old to adult). A novel 'litter-based' model for investigating blood-CSF barrier exchange in immature animals is described. 2. At each age investigated there was a clear inverse correlation between molecular radius and blood-CSF barrier exchange, in addition to an overall decrease in blood-CSF barrier exchange with increasing age. 3. The decrease in blood-CSF barrier exchange with age was not consistent with a reduction in pore diameters, nor does it appear to be due to an increase in the CSF sink effect with age. It seems likely to be due to a relative decrease in the number of a population of large diameter pores.
Keywords
Animals, Biological Markers, Blood-Brain Barrier/physiology, Brain/growth & development, Cerebrospinal Fluid/physiology, Diffusion, Immunoglobulin G/blood, Immunoglobulin G/cerebrospinal fluid, Inulin/blood, Inulin/cerebrospinal fluid, Models, Biological, Permeability, Rats, Solubility, Sucrose/blood, Sucrose/cerebrospinal fluid
Pubmed
Web of science
Create date
24/01/2008 14:26
Last modification date
20/08/2019 15:16
Usage data