Do testicular seminoma and nonseminoma share the same etiology?: evidence from an age-period-cohort analysis of incidence trends in eight European countries

Details

Serval ID
serval:BIB_ACC2FA0C0227
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Do testicular seminoma and nonseminoma share the same etiology?: evidence from an age-period-cohort analysis of incidence trends in eight European countries
Journal
Cancer Epidemiology, Biomarkers and Prevention
Author(s)
Bray Freddie, Richiardi Lorenzo, Ekbom Anders, Forman David, Pukkala Eero, Cuninkova Martina, Møller Henrik, European Network of Cancer Registries
ISSN
1055-9965
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
15
Number
4
Pages
652-658
Language
english
Notes
SAPHIRID:57844
Abstract
The incidence of the two main clinical subentities of testicular germ cell cancer (seminoma and nonseminoma) is increasing throughout Europe. Most studies have revealed little variation in risk factors between the two subtypes. This study compared generation-specific trends in eight European countries, hypothesizing that similar temporal pattern by birth cohort implied that seminoma and nonseminoma had a largely comparable etiology. The results are presented using the age-period-cohort model and the nonidentifiability problem highlighted by partitioning the age, period, and cohort effects in terms of their linear and curvature component parts, assuming a priori that cohort effects predominated. Despite uniform overall increases by calendar period, declining rates of nonseminoma but not pure seminoma were observed in the majority of countries during the 1990s. The subtype trends were, however, largely analogous on a birth cohort scale. Notable observations were a decline in rates of both subtypes among recent birth cohorts in Switzerland and a short-term wartime effect in several countries, involving an attenuation of increasing risk of both subtypes in men born in 1940 to 1945. Departures from the steady increases in testicular cancer over time were likely to occur for nonseminomas some years ahead of seminoma on a period scale. The importance of birth cohort coincided with the view that given a short time interval of susceptibility to exposures earlier in life and a biologically constant time to diagnosis, all temporal changes in rate-limiting exposures should appear as generational effects. Trends in seminoma and nonseminoma conform to largely the same temporal patterns on this scale, implying that they share important etiologic factors. [Authors]
Pubmed
Web of science
Open Access
Yes
Create date
04/03/2008 14:58
Last modification date
20/08/2019 15:16
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