Using high-resolution quantitative mapping of R1 as an index of cortical myelination

Details

Serval ID
serval:BIB_ACB89F61CF8A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Using high-resolution quantitative mapping of R1 as an index of cortical myelination
Journal
NeuroImage
Author(s)
Lutti Antoine, Dick Frederic, Sereno Martin I., Weiskopf Nikolaus
ISSN
1053-8119 (Print)
ISSN-L
1053-8119
Publication state
Published
Issued date
2014
Volume
93
Pages
176-188
Language
english
Notes
Publication types: JOURNAL ARTICLE pdf: Review
Abstract
A fundamental tenet of neuroscience is that cortical functional differentiation is related to the cross-areal differences in cyto-, receptor-, and myeloarchitectonics that are observed in ex-vivo preparations. An ongoing challenge is to create noninvasive magnetic resonance (MR) imaging techniques that offer sufficient resolution, tissue contrast, accuracy and precision to allow for characterization of cortical architecture over an entire living human brain. One exciting development is the advent of fast, high-resolution quantitative mapping of basic MR parameters that reflect cortical myeloarchitecture. Here, we outline some of the theoretical and technical advances underlying this technique, particularly in terms of measuring and correcting for transmit and receive radio frequency field inhomogeneities. We also discuss new directions in analytic techniques, including higher resolution reconstructions of the cortical surface. We then discuss two recent applications of this technique. The first compares individual and group myelin maps to functional retinotopic maps in the same individuals, demonstrating a close relationship between functionally and myeloarchitectonically defined areal boundaries (as well as revealing an interesting disparity in a highly studied visual area). The second combines tonotopic and myeloarchitectonic mapping to localize primary auditory areas in individual healthy adults, using a similar strategy as combined electrophysiological and post-mortem myeloarchitectonic studies in non-human primates.
Pubmed
Web of science
Create date
08/07/2013 11:06
Last modification date
20/08/2019 16:16
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