Prevention of renal hypertension in the rat by neuropeptide Y.

Details

Serval ID
serval:BIB_AC973EDF204C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prevention of renal hypertension in the rat by neuropeptide Y.
Journal
Journal of Hypertension
Author(s)
Waeber B., Evéquoz D., Aubert J.F., Flückiger J.P., Juillerat L., Nussberger J., Brunner H.R.
ISSN
0263-6352
Publication state
Published
Issued date
1990
Peer-reviewed
Oui
Volume
8
Number
1
Pages
21-25
Language
english
Notes
Journal Article --- Old month value: Jan
Abstract
Neuropeptide Y is known to enhance blood pressure responsiveness to various constrictors, including angiotensin II, and to suppress renin secretion. This study was undertaken to assess the effect of neuropeptide Y on the development of two-kidney, one clip renal hypertension. Normotensive rats either had a silver clip placed on the left renal artery or were sham-operated upon. An osmotic minipump, which was connected via a catheter to a jugular vein, was implanted subcutaneously in all rats. These pumps delivered either neuropeptide Y (0.001 microgram/min) or saline intravenously. Eight days later, an intra-arterial catheter was inserted and the rats were studied while not anesthetized on the following day. Neuropeptide Y did not affect body weight. In clipped rats, neuropeptide Y prevented the development of hypertension and suppressed renin secretion. Neuropeptide Y significantly decreased blood pressure also in sham-operated rats, although it had no effect on plasma renin activity. These data indicate that prolonged neuropeptide Y infusion may lower blood pressure by different mechanisms, one of which is probably a suppression of renin release.
Keywords
Animals, Blood Pressure, Body Weight, Hypertension, Renovascular, Infusion Pumps, Implantable, Male, Neuropeptide Y, Rats, Rats, Inbred Strains, Renin, Renin-Angiotensin System
Pubmed
Web of science
Create date
05/03/2008 16:39
Last modification date
20/08/2019 15:16
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