Developmental and spatial expression pattern of syntaxin 13 in the mouse central nervous system

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Serval ID
serval:BIB_AC6E9B676BFA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Developmental and spatial expression pattern of syntaxin 13 in the mouse central nervous system
Journal
Cell and Tissue Research
Author(s)
Sarria  J. C., Catsicas  S., Hornung  J. P., Hirling  H.
ISSN
0302-766X (Print)
Publication state
Published
Issued date
08/2002
Volume
309
Number
2
Pages
209-18
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug
Abstract
Vesicular transport involves SNARE (soluble- N-ethylmaleimide-sensitive-factor-attachment-protein-receptor) proteins on transport vesicles and on target membranes. Syntaxin 13 is a SNARE enriched in brain, associated with recycling endosomes; its overexpression in PC12 cells promotes neurite outgrowth. This suggests an important role for receptor recycling during neuronal differentiation. Here we describe the spatiotemporal pattern of syntaxin 13 expression during mouse brain development. During early embryogenesis (E12-E15), it was found in the forebrain ventricular zone and in primary motor and sensory neurons in the brainstem, spinal cord and sensory ganglia. In the forebrain at E15, syntaxin 13 was not detected in neuroblasts in the intermediate zone of the embryonic hemispheric wall, while there was labeling in cortical neurons in deeper layers starting at E15-18, and progressively in later-generated neurons up to layer II around P6. Syntaxin 13 reached maximal expression in all brain divisions at about P7, followed by a decrease, with heterogeneous neuron populations displaying various staining intensities in adult brain. While usually restricted to the soma of neurons, we transiently detected syntaxin 13 in dendrites of pyramidal neurons during the first postnatal week. In conclusion, the developmentally regulated syntaxin 13 expression in various neuronal populations is consistent with its involvement in endocytic trafficking and neurite outgrowth.
Keywords
Aging Animals Animals, Newborn Brain/*embryology/growth & development/*metabolism Dendrites/metabolism Immunohistochemistry In Situ Hybridization Membrane Proteins/*metabolism Mice Mice, Inbred C3H Neurons/cytology/*metabolism Qa-SNARE Proteins
Pubmed
Web of science
Create date
24/01/2008 15:22
Last modification date
20/08/2019 16:16
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