A potent converting enzyme inhibitor CGS 13928C. Drug profile in normal volunteers

Details

Serval ID
serval:BIB_ABF628ED1771
Type
Article: article from journal or magazin.
Collection
Publications
Title
A potent converting enzyme inhibitor CGS 13928C. Drug profile in normal volunteers
Journal
European Journal of Clinical Pharmacology
Author(s)
Schaller  M. D., Brunner  D. B., Nussberger  J., Turini  G. A., Sen  S. B., Chen  D., Waeber  B., Brunner  H. R.
ISSN
0031-6970 (Print)
Publication state
Published
Issued date
1984
Volume
26
Number
4
Pages
419-24
Notes
Journal Article
Research Support, Non-U.S. Gov't
Abstract
The converting enzyme inhibitor CGS 13928C was evaluated in 15 healthy male volunteers. First the efficacy of a single oral dose of 0.5, 1, 2 or 5 mg in antagonizing the pressor response to exogenous angiotensin I was tested with continuous monitoring of the blood pressure and heart rate by an intraarterial catheter. CGS 13928C 1, 2 and 5 mg consistently reduced the response to angiotensin within 2 to 3 h and for a period exceeding the 4 h of monitoring. The 2 mg dose was hardly more effective than 1 mg and 5 mg did not further enhance the blockade. Subsequently, plasma renin and converting enzyme activity, angiotensin I, angiotensin II and aldosterone were measured serially before and up to 72 h following oral administration of either 1 mg (n = 7) or 2 mg (n = 8) CGS 13928C. As expected, plasma renin activity and angiotensin I rose, while plasma converting enzyme activity, angiotensin II and aldosterone fell following both doses of the drug. No side-effects occurred. In normal volunteers CGS 13928C is an effective and extremely potent, orally active converting enzyme inhibitor.
Keywords
Adult Angiotensin I/pharmacology *Angiotensin-Converting Enzyme Inhibitors Blood Pressure/*drug effects Dose-Response Relationship, Drug Drug Evaluation Heart Rate/drug effects Humans Indoles/*pharmacology Male Pressoreceptors/drug effects Renin-Angiotensin System/*drug effects Time Factors
Pubmed
Web of science
Create date
05/03/2008 17:39
Last modification date
20/08/2019 16:15
Usage data