The link between impaired oxygen supply and cognitive decline in peripheral artery disease.

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Ressource 1Download: 437. Burtscher ProgressCardiovascularMedicine23ip oxygenSupply CognitiveDecline PAD.pdf (1220.37 [Ko])
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Version: Final published version
License: CC BY-NC-ND 4.0
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State: Public
Version: Final published version
License: Not specified
Serval ID
serval:BIB_ABD491968817
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The link between impaired oxygen supply and cognitive decline in peripheral artery disease.
Journal
Progress in cardiovascular diseases
Author(s)
Burtscher J., Millet G.P., Fresa M., Lanzi S., Mazzolai L., Pellegrin M.
ISSN
1873-1740 (Electronic)
ISSN-L
0033-0620
Publication state
Published
Issued date
2024
Volume
85
Pages
63-73
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Although peripheral artery disease (PAD) primarily affects large arteries outside the brain, PAD is also associated with elevated cerebral vulnerabilities, including greater risks for brain injury (such as stroke), cognitive decline and dementia. In the present review, we aim to evaluate recent literature and extract information on potential mechanisms linking PAD and consequences on the brain. Furthermore, we suggest novel therapeutic avenues to mitigate cognitive decline and reduce risk of brain injury in patients with PAD. Various interventions, notably exercise, directly or indirectly improve systemic blood flow and oxygen supply and are effective strategies in patients with PAD or cognitive decline. Moreover, triggering protective cellular and systemic mechanisms by modulating inspired oxygen concentrations are emerging as potential novel treatment strategies. While several genetic and pharmacological approaches to modulate adaptations to hypoxia showed promising results in preclinical models of PAD, no clear benefits have yet been clinically demonstrated. We argue that genetic/pharmacological regulation of the involved adaptive systems remains challenging but that therapeutic variation of inspired oxygen levels (e.g., hypoxia conditioning) are promising future interventions to mitigate associated cognitive decline in patients with PAD.
Keywords
Humans, Peripheral Arterial Disease/metabolism, Peripheral Arterial Disease/physiopathology, Peripheral Arterial Disease/therapy, Cognitive Dysfunction/metabolism, Cognitive Dysfunction/etiology, Cognitive Dysfunction/physiopathology, Cognitive Dysfunction/psychology, Cognitive Dysfunction/prevention & control, Cognition, Oxygen/metabolism, Animals, Cerebrovascular Circulation, Risk Factors, Brain/metabolism, Brain/physiopathology, Brain/blood supply, Cardiovascular disease, Dementia, Exercise, Hypoxia, Peripheral artery disease
Pubmed
Open Access
Yes
Create date
15/12/2023 15:29
Last modification date
24/09/2024 7:19
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