Persistent decreased plasma cholecystokinin levels in celiac patients under gluten-free diet: respective roles of histological changes and nutrient hydrolysis.

Details

Serval ID
serval:BIB_ABC86046F7D3
Type
Article: article from journal or magazin.
Collection
Publications
Title
Persistent decreased plasma cholecystokinin levels in celiac patients under gluten-free diet: respective roles of histological changes and nutrient hydrolysis.
Journal
Regulatory Peptides
Author(s)
Deprez P., Sempoux C., Van Beers B.E., Jouret A., Robert A., Rahier J., Geubel A., Pauwels S., Mainguet P.
ISSN
0167-0115 (Print)
ISSN-L
0167-0115
Publication state
Published
Issued date
2002
Peer-reviewed
Oui
Volume
110
Number
1
Pages
55-63
Language
english
Notes
Publication types: Comparative Study ; Journal ArticlePublication Status: ppublish
Abstract
Celiac disease is associated with impaired cholecystokinin (CCK) release. The mechanism by which CCK release is impaired is poorly understood and seems to be related to the mucosal atrophy or to decreased stimulation due to reduced intraduodenal nutrient hydrolysis. The aims of our study were to evaluate basal and postprandial CCK in celiac patients presenting with distinctive types of mucosal lesions (normal, infiltrative and atrophic), and to study the role of protein hydrolysis on CCK release. Plasma CCK was measured in 20 celiac patients (normal mucosa: n=6; infiltrative type: n=6; atrophic type=8) and 9 controls, before and after ingestion of a polymeric or a semi-elemental meal. Significant decreases in basal CCK plasma (B 0.6 [95% CI, 0.3-1.3] pmol/l; p<0.003) and postprandial CCK area under curve (AUC 34 [19-61] pmol/l x 120 min, p<0.0001) were observed in patients with an atrophic mucosa compared with treated patients (B 1.6 [1.0-2.4] pmol/l, AUC 267 [172-414] pmol/l x 120 min) or healthy volunteers (B 1.0 [0.7-1.4] pmol/l, AUC 186 [131-264] pmol/l x 120 min). A significant defective CCK release was also observed in patients with an infiltrative type: B 0.4 [0.2-0.7] pmol/l and AUC 56 [31-101] pmol/l x 120 min; p<0.0001. Administration of a semi-elemental diet did not correct the defective CCK release. In conclusion, the decreased CCK levels observed in celiac patients are not strictly related to the mucosal atrophy but rather to the lymphocytic infiltrate. Administration of a predigested meal did not correct the impaired CCK release. Some inhibitory mechanism could be involved in the CCK cell dysfunction observed in celiac patients presenting with lesser degrees of disease activity.
Keywords
Adult, Area Under Curve, Atrophy, Celiac Disease/blood, Celiac Disease/diet therapy, Cholecystokinin/blood, Dietary Proteins/metabolism, Female, Food, Formulated, Gallbladder/physiopathology, Glutens/administration & dosage, Humans, Hydrolysis, Intestinal Mucosa/metabolism, Intestinal Mucosa/pathology, Lymphocytes/pathology, Male, Postprandial Period, Radioimmunoassay
Pubmed
Web of science
Create date
20/10/2016 16:29
Last modification date
20/08/2019 15:15
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