MAF drives CD8(+) T-cell exhaustion.

Details

Serval ID
serval:BIB_ABC5C38C8BC5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
MAF drives CD8(+) T-cell exhaustion.
Journal
Oncoimmunology
Author(s)
Verdeil G.
ISSN
2162-4011 (Print)
ISSN-L
2162-4011
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
5
Number
2
Pages
e1082707
Language
english
Notes
Publication types: ARTICLE Publication Status: epublish
Abstract
The molecular regulation of tumor induced T-cell exhaustion remains poorly characterized. Recently, we compared the transcriptome of "exhausted" CD8(+) T cells infiltrating melanomas to those of naive and acutely stimulated CD8(+) T cells. We demonstrated that MAF is over-expressed and plays a key role in driving the transcriptional program of T-cell exhaustion.
Pubmed
Web of science
Create date
19/04/2016 17:29
Last modification date
07/04/2021 5:34
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