Value of a new screening test for respiratory allergy

Details

Serval ID
serval:BIB_ABB94D06D7D5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Value of a new screening test for respiratory allergy
Journal
Allergy
Author(s)
Duc  J., Peitrequin  R., Pecoud  A.
ISSN
0105-4538 (Print)
Publication state
Published
Issued date
07/1988
Volume
43
Number
5
Pages
332-7
Notes
Journal Article --- Old month value: Jul
Abstract
Phadiatop (Pharmacia) is a new in vitro screening test for respiratory allergy which detects in serum the presence of specific IgE to a mixture of common inhalant allergens; results are either positive or negative. Among 100 patients suffering from rhinitis and/or asthma, investigated with 15 skin prick tests (SPT) and RAST for frequent allergens, the Phadiatop was positive in 63: all 63 had at least one positive SPT and RAST (specificity: 100%). Conversely, ther were 67 patients who had a positive RAST for at least one allergen: among these 67 the total IgE concentration in serum was high (greater than 100 kU/l) in 43 (64%) and the Phadiatop was positive in 63 (94%). Phadiatop was negative in serum obtained from 10 cord bloods and 10 non-allergic subjects (disease-free, 15 negative SPT and RAST). Results of the radio-immunoassay originally proposed by the manufacturer were similar to those obtained with a modified enzymo assay using a fluorometric substrate. In the prediction of respiratory allergy, Phadiatop was found to be specific and more accurate than the determination of total IgE in serum.
Keywords
Adolescent Adult Allergens Asthma/diagnosis Female Humans Hypersensitivity, Immediate/*diagnosis Immunoglobulin E/analysis Male Middle Aged Radioallergosorbent Test/*methods Radioimmunoassay/*methods Rhinitis, Allergic, Perennial/diagnosis Rhinitis, Allergic, Seasonal/diagnosis
Pubmed
Web of science
Create date
28/01/2008 11:58
Last modification date
20/08/2019 15:15
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