PTLD Burkitt Lymphoma in a Patient with Remote Lymphomatoid Granulomatosis.

Details

Ressource 1Download: BIB_AB92C502EDD1.P001.pdf (2483.47 [Ko])
State: Public
Version: author
Serval ID
serval:BIB_AB92C502EDD1
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
PTLD Burkitt Lymphoma in a Patient with Remote Lymphomatoid Granulomatosis.
Journal
Case Reports In Medicine
Author(s)
Stravodimou A., Cairoli A., Rausch T., Du Pasquier R., Michel P.
ISSN
1687-9635 (Electronic)
Publication state
Published
Issued date
2012
Volume
2012
Pages
239719
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Posttransplant lymphoproliferative disorder (PTLD) is a potentially fatal complication of solid organ transplantation. The majority of PTLD is of B-cell origin, and 90% are associated with the Epstein-Barr virus (EBV). Lymphomatoid granulomatosis (LG) is a rare, EBV-associated systemic angiodestructive lymphoproliferative disorder, which has rarely been described in patients with renal transplantation. We report the case of a patient with renal transplantation for SLE, who presented, 9 months after renal transplantation, an EBV-associated LG limited to the intracranial structures that recovered completely after adjustment of her immunosuppressive treatment. Nine years later, she developed a second PTLD disorder with central nervous system initial manifestation. Workup revealed an EBV-positive PTLD Burkitt lymphoma, widely disseminated in most organs. In summary, the reported patient presented two lymphoproliferative disorders (LG and Burkitt's lymphoma), both with initial neurological manifestation, at 9 years interval. With careful reduction of the immunosuppression after the first manifestation and with the use of chemotherapy combined with radiotherapy after the second manifestation, our patient showed complete disappearance of neurologic symptoms and she is clinically well with good kidney function. No recurrence has been observed by radiological imaging until now.
Pubmed
Open Access
Yes
Create date
17/01/2013 15:17
Last modification date
20/08/2019 16:15
Usage data