Programmed death ligand 2 expression plays a limited role in adenocarcinomas of the gastroesophageal junction after preoperative chemotherapy

Details

Serval ID
serval:BIB_AB80F98C298F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Programmed death ligand 2 expression plays a limited role in adenocarcinomas of the gastroesophageal junction after preoperative chemotherapy
Journal
European Surgery
Author(s)
Jomrich Gerd, Kollmann Dagmar, Wilfing Lavinia, Radosavljevic Sanja, Ramazanova Dariga, Ristl Robin, Grose Richard P., Ilhan-Mutlu Aysegül, Preusser Matthias, Fassnacht Christina, Tsai Yi-Chien, Guenova Emmanuella (co-last), Schoppmann Sebastian F.
ISSN
1682-8631
1682-4016
Publication state
In Press
Language
english
Abstract
Background The effects of cytotoxic chemotherapy on the expression of programmed death ligand 2 (PD-L2) are unknown and little is known about how the tumor microenvironment changes following neoadjuvant chemotherapy in locally advanced gastroesophageal adenocarcinomas (AEG). Recently, a number of studies reported that cytotoxic chemotherapy affects the expression levels of programmed cell death protein 1 (PD-1) and its ligand 1 (PD-L1). Regarding PD-L2, the second known ligand of PD-1, no data on potential changes in expression patterns in patients with preoperatively treated AEG are available. The aim of this study was to investigate the impact of cytotoxic chemotherapy on PD-L2 expression in patients with resectable AEG. Methods Consecutive patients with locally advanced AEG treated with preoperative cytotoxic chemotherapy were included. PD-L2 expression by cancer cells (CCs) and tumor-infiltrating lymphocytes (TILs) was investigated in samples of paired diagnostic biopsies and resected tumor specimens by immunohistochemistry using two different anti-PD-L2 antibodies. Results Included were 40 patients with AEG and available paired tumor tissue samples. PD-L2 expression was observed in one diagnostic biopsy sample by CCs and in one diagnostic biopsy sample by TILs. There was no difference concerning the expression levels measured by the two antibodies. Conclusion In contrast to previously published studies reporting PD-L2 expression rates of up to 50% in AEGs, in our cohort, PD-L2 expression seems to play no significant role in AEG.
Keywords
Surgery
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation / PMPDP3_151326
Create date
21/05/2021 17:13
Last modification date
04/06/2021 6:38
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